06-1079 | Anti-Interleukin 23 alpha (IL-23A) Antibody

06-1079
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1079
      DescriptionAnti-Interleukin 23 alpha (IL-23A) Antibody
      Alternate Names
      • IL-23 subunit alpha
      • Interleukin-23 subunit p19
      • JKA3 induced upon T-cell activation
      • interleukin 23 p19 subunit
      • interleukin 23, alpha subunit p19
      Background InformationInterleukin-23 subunit alpha (IL-23A or IL-23, p19 subunit) is a subunit of heterodimeric cytokine IL-23, which also contains the p40 subunit of interleukin 12 (IL-12B). The receptor of IL-23 is formed by the beta 1 subunit of IL-12 (IL-12RB1) and an IL-23 specific subunit, IL-23R. IL-23 activates the transcription activator STAT4, and stimulates the production of interferon-gamma. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation.
      References
      Product Information
      FormatAffinity Purified
      Control
      • 3T3/A31 cell lysate
      PresentationPurified rabbit polyclonal in PBS with 0.09% sodium azide.
      Applications
      ApplicationDetect Interleukin 23 alpha (IL-23A) using this Anti-Interleukin 23 alpha (IL-23A) Antibody validated for use in WB, FC.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a previous lot detected IL-23 alpha in human PBMC's.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the mature chain of human IL-23 subunit alpha.
      EpitopeMature chain of IL-23, subunit alpha.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityAntibody recognizes the mature chain of IL-23 subunit alpha.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with human and mouse.
      Predicted to react with rhesus monkey based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq].
      Gene Symbol
      • IL23A
      • IL-23
      • IL-23A
      • IL-23p19
      • IL23P19
      • P19
      • SGRF
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

      SUBUNIT STRUCTURE: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

      SUBCELLULAR LOCATION: Secreted. Note: Secreted upon association with IL12B.

      TISSUE SPECIFICTY: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

      DEVELOPMENTAL STAGE: Expressed by newborns dendritic cells.

      INDUCTION: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.

      SEQUENCE SIMILARITIES: Belongs to the IL-6 superfamily.
      Molecular WeightUniProtKB/Swiss-Prot entry Q9NPF7 lists a molecular weight of 20.730 kDa. In some lysates tested, non-specific bands are observed at around 40 kDa and around 55 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in 3T3/A31 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected IL-23 alpha in 10 µg of 3T3/A31 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications