06-1083 | Anti-Interleukin 4 (IL-4) Antibody

06-1083
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Eq, ChpWB, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1083
      DescriptionAnti-Interleukin 4 (IL-4) Antibody
      Alternate Names
      • B cell growth factor 1
      • B-cell stimulatory factor 1
      • B_cell stimulatory factor 1
      • Lymphocyte stimulatory factor 1
      • interleukin 4
      Background InformationInterleukin-4 (IL-4) is a cytokine that stimulates activated B-cell and T-cell proliferation and induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. These Th2 cells, in turn, also produce IL-4. IL-4 also acts as a key regulator in humoral and adaptive immunity and induces B-cell class switching to IgE, as well as up-regulating MHC class II production. Mutations in the IL-4 gene may lead to a susceptibility to ischemic stroke or cerebral infarction. Overproduction of IL-4 is associated with allergies.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Recombinant human IL-4.
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.09% sodium azide.
      Applications
      ApplicationAnti-Interleukin 4 (IL-4) Antibody is an antibody against Interleukin 4 (IL-4) for use in WB, FC.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a previous lot detected IL-4 in human PBMCs.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the mature chain of IL-4.
      EpitopeMature chain of IL-4.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityAntibody recognizes IL-4, mature chain.
      Species Reactivity
      • Human
      • Mouse
      • Horse
      • Chimpanzee
      Species Reactivity NoteDemonstrated to react with human and mouse.
      Predicted to react with Horse, Chimpanzee and Rhesus Monkey based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq].
      Gene Symbol
      • IL4
      • Binetrakin
      • Pitrakinra
      • BSF1
      • BSF-1
      • IL-4
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

      SIZE: 153 amino acids; 17492 Da

      SUBCELLULAR LOCATION: Secreted.

      DISEASE: Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

      SIMILARITY: Belongs to the IL-4/IL-13 family.
      Molecular WeightUniProtKB/Swiss-Prot entry P05112 (IL4_HUMAN) describes 2 isoforms produced by alternative splicing: isoform 1 at 18 kDa and isoform 2 at 16 kDa. Recombinant Human Interleukin-4 (Millipore Cat # IL004) is observed at 15 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot on recombinant human IL-4.

      Western Blot Analysis: 1 µg/mL of this antibody detected recombinant human IL-4
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies