CBL2117 | Anti-Interleukin-6 Antibody, clone B-E8

CBL2117
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, FC, IHC, NEUTMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL2117
      Replaces04-1095
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Interleukin-6 Antibody, clone B-E8
      Alternate Names
      • IL-6
      • B-cell stimulatory factor 2
      • Interferon beta-2
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is purified from tissue culture supernatant by ion exchange chromatography and is presented as a liquid in phosphate buffered saline, pH 7.2, containing 0.09% sodium azide.
      Applications
      ApplicationDetect Interleukin-6 using this Anti-Interleukin-6 Antibody, clone B-E8 validated for use in ELISA, FC, IH, NEUT.
      Key Applications
      • ELISA
      • Flow Cytometry
      • Immunohistochemistry
      • Neutralizing
      Application NotesBlocks Interleukin-6 induced proliferation on B9 cells: 20pg of antibody neutralizes the activity of 1U of IL-6. It is recommended that the sodium azide is removed from the antibody prior to use in this application.

      Immunohistochemistry on frozen sections

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenRecombinant human IL-6.
      CloneB-E8
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes natural and recombinant forms of human Interleukin-6 with an affinity of 0.5 nM. Inhibits IL-6 binding to its receptors and blocks Interleukin-6 induced proliferation on B9 cells.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IL6
      • HSF
      • BSF-2
      • HGF
      • IL-6
      • BSF2
      • CDF
      • IFNB2
      Non-Reactive Species
      • Mouse
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05231 # IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
      SIZE: 212 amino acids; 23718 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: N- and O-glycosylated.
      DISEASE: SwissProt: P05231 # Genetic variations in IL6 are associated with susceptibility to systemic juvenile rheumatoid arthritis [MIM:604302]. Systemic juvenile rheumatoid arthritis is juvenile chronic arthritis associated with severe, debilitating, extraarticular features, and occasionally fatal complications. Despite medical treatment, many children still experience early joint destruction, necessitating surgical replacement. & At least 1 polymorphism in the IL6 gene renders HIV- infected men susceptible to Kaposi sarcoma [MIM:148000]. Kaposi sarcoma is a sarcoma of spindle cells mixed with angiomatous tissue. A relatively rare malignant skin tumor that results in multifocal purplish coloured papules or plaques that eventually form nodules. Most commonly seen in patients who suffer from AIDS.
      SIMILARITY: SwissProt: P05231 ## Belongs to the IL-6 superfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C for up to 12 months from date of receipt. For long term storage aliquot antibody into small volumes and store at -20°C. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN INTERLEUKIN-6 2484078
      MOUSE ANTI-HUMAN INTERLEUKIN-6 MONOCLONAL ANTIBODY - 2470331 2470331
      MOUSE ANTI-HUMAN INTERLEUKIN-6 -2605441 2605441
      MOUSE ANTI-HUMAN INTERLEUKIN-6 -2632545 2632545
      MOUSE ANTI-HUMAN INTERLEUKIN-6 -2716611 2716611
      MOUSE ANTI-HUMAN INTERLEUKIN-6 -2860176 2860176
      MOUSE ANTI-HUMAN INTERLEUKIN-6 MONOCLONAL ANTIBODY 2965864
      MOUSE ANTI-HUMAN INTERLEUKIN-6 MONOCLONAL ANTIBODY 2967784
      MOUSE ANTI-HUMAN INTERLEUKIN-6 MONOCLONAL ANTIBODY - 2159623 2159623
      MOUSE ANTI-HUMAN INTERLEUKIN-6 MONOCLONAL ANTIBODY - 2302728 2302728

      References

      Reference overviewPub Med ID
      Maternal immune activation alters behavior in adult offspring, with subtle changes in the cortical transcriptome and epigenome.
      Connor, CM; Dincer, A; Straubhaar, J; Galler, JR; Houston, IB; Akbarian, S
      Schizophrenia research  140  175-84  2012

      Show Abstract
      22804924 22804924
      Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner.
      Fang Huang,Kang Liu,Hang Du,Junping Kou,Baolin Liu
      Biochimie  94  2012

      Show Abstract
      22314193 22314193
      Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes.
      Tianjiong Lou,Zhongai Zhang,Zhilei Xi,Kang Liu,Lin Li,Baolin Liu,Fang Huang
      Inflammation  34  2011

      Show Abstract
      21110076 21110076
      Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions.
      Balini Balasubramaniam,Debra A Carter,Eric J Mayer,Andrew D Dick
      Experimental eye research  89  2009

      Show Abstract
      19596318 19596318
      Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise.
      Penkowa, M; Keller, C; Keller, P; Jauffred, S; Pedersen, BK
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  17  2166-8  2003

      Show Abstract
      12958150 12958150
      Elevated levels of IL-18 in plasma and skeletal muscle in chronic obstructive pulmonary disease.
      A M W Petersen,M Penkowa,M Iversen,L Frydelund-Larsen,J L Andersen,J Mortensen,P Lange,B K Pedersen
      Lung  185  2001

      Show Abstract
      17436040 17436040

      Data Sheet

      Title
      Anti-Interleukin-6, clone B-E8 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies