06-665 | Anti-JAK1 Antibody

06-665
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-665
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-JAK1 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
      Applications
      ApplicationAnti-JAK1 Antibody is an antibody against JAK1 for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein containing amino acids 649-747 of human JAK1
      HostRabbit
      SpecificityJAK1
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryJanus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
      Gene Symbol
      • JAK1
      • JAK1B
      • JAK1A
      • JAK-1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23458 # Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
      SIZE: 1142 amino acids; 131957 Da
      SUBUNIT: Interacts with IL31RA and SHB.
      SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
      DOMAIN: SwissProt: P23458 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.
      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
      Molecular Weight130kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitating JAK1 from human TF1 RIPA lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-JAK1 - 16287 16287
      Anti-JAK1 - 30810 30810

      References

      Reference overviewApplicationPub Med ID
      IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines.
      Sabita Sankar, Henry Chan, William J Romanow, Jianwu Li, R J Bates
      Cellular signalling  18  982-93  2006

      Show Abstract
      16199137 16199137
      T cell antigen receptor-mediated activation of the Ras/mitogen-activated protein kinase pathway controls interleukin 4 receptor function and type-2 helper T cell differentiation.
      Yamashita, M, et al.
      Proc. Natl. Acad. Sci. U.S.A., 96: 1024-9 (1999)  1999

      Show Abstract
      Immunoblotting (Western)9927687 9927687
      JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.
      Witthuhn, B A, et al.
      Cell, 74: 227-36 (1993)  1993

      Show Abstract
      8343951 8343951
      Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.
      Argetsinger, L S, et al.
      Cell, 74: 237-44 (1993)  1993

      Show Abstract
      8343952 8343952
      Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation.
      Silvennoinen, O, et al.
      Science, 261: 1736-9 (1993)  1993

      Show Abstract
      8378775 8378775

      Technical Info

      Title
      JAK/STAT Signaling Research Focus

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies