09-817 Anti-JMJD1C Antibody

09-817
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Rb, Chp, Rhesus MacaqueWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number09-817
      DescriptionAnti-JMJD1C Antibody
      Alternate Names
      • JMJD
      • jumonji domain containing 1C
      • TR-interacting protein 8
      • thyroid receptor interacting protein 8
      • probable JmjC domain-containing histone demethylation protein 2C
      • thyroid hormone receptor interactor 8
      • Thyroid receptor-interacting protein 8
      • Jumonji domain-containing protein 1C
      Background InformationJMJD1C (jumonji domain-containing protein 1C) is also known as TRIP8 and mutations in this histone demethylase have been linked to certain forms of autism. JMJD1C is also thought to work in reactivating genes in embryonic stem cells, pancreatic islet and gastric cancer. JMJD1C has also been implicated as a gene expression regulator. JMJD1C with WHISTLE have recently been shown to also play a role in mouse testis development. JMJD1C has been identified as a nuclear-receptor coactivator and is a candidate gene for autism.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa nuclear extract
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-JMJD1C Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect JMJD1C also known as jumonji domain containing 1C or TR-interacting protein 8.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected JMJD1C in HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human JMJD1C.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rabbit
      • Chimpanzee
      • Rhesus Macaque
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Rabbit, Chimpanzee, Rhesus Macaque, and Orangutan based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRIP8
      • RP11-10C13.2
      • JMJD1C
      • JHDM2C
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

      COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).

      SUBUNIT STRUCTURE: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.

      SUBCELLULAR LOCATION: Nucleus (By similarity).

      DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

      SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.

      Contains 1 JmjC domain.

      SEQUENCE CAUTION: The sequence AAC41741.1 differs from that shown. Reason: Frameshift at position 2171.

      The sequence CAD97921.1 differs from that shown. Reason: Frameshift at position 1697.

      The sequence CAI10947.1 differs from that shown. Reason: Erroneous gene model prediction.
      Molecular Weight~284 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa nuclear extract.

      Western Blot Analysis: 1 µg/mL of this antibody detected JMJD1C on 10 µg of HeLa nuclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies