06-1097 | Anti-Jagged2 Antibody

06-1097
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), ELISARbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1097
      DescriptionAnti-Jagged2 Antibody
      Alternate Names
      • jagged 2
      • Jagged2
      Background InformationJagged 2 is a notch ligand belonging to the Notch gene family and is a necessary component for embryonic development. Notch is the receptor for Delta and Jagged ligands, which cause proteolysis of notch to liberate the intracellular domain. It is expressed in the heart, placenta and skeletal muscle and some expression is found in the pancreas, brain, lung, liver and kidney. Mutations in Jagged2 may be associated with multiple myeloma.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Ductal carcinoma in situ tissue
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-Jagged2 Antibody is validated for use in IH(P), ELISA for the detection of Jagged2.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • ELISA
      Application NotesSpecificity confirmed with direct ELISA.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Jagged2.
      EpitopeCytoplasmic
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Jagged2 at the cytoplasmic domain.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human. Other homologies: Rat (83% sequence homology). Mouse (75% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
      Gene Symbol
      • HJ2
      • SER2
      • JAG2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      TISSUE SPECIFICTY: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.

      SEQUENCE SIMILARITIES: Contains 1 DSL domain.

      Contains 16 EGF-like domains.

      Contains 1 VWFC domain.
      Molecular Weight133 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in ductal carcinoma in situ tissue.

      Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Jagged2 in ductal carcinoma in situ tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications