05-554-25UG | Anti-KDR/Flk-1 Antibody, clone CH-11

New05-554-25UG
25 μg  
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      Overview

      Replacement Information
      Description
      Catalogue Number05-554-25UG
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-KDR/Flk-1 Antibody, clone CH-11
      References
      Product Information
      FormatPurified
      Presentation20mM sodium phosphate, pH 7.6, 250mM NaCl with 0.1% sodium azide
      Applications
      ApplicationAnti-KDR/Flk-1/VEGFR2 Antibody, clone CH-11 detects level of KDR/Flk-1/VEGFR2 & has been published & validated for use in ELISA, IC & WB.
      Key Applications
      • ELISA
      • Immunocytochemistry
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to residues 1158-1345 of murine KDR/Flk-1
      Cloneclone CH-11
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityKDR/Flk-1
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KDR
      • VEGFR-2
      • VEGFR2
      • VEGFR
      • CD309
      • FLK1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35968 # Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1356 amino acids; 151527 Da
      SUBUNIT: Interacts with SHB upon VEGF activation. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P35968 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight230kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from HUVEC cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at 4°C
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

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