04-640 | Anti-LAP2α Antibody, clone 3A3

04-640
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IFMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-640
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-LAP2α Antibody, clone 3A3
      Background InformationThe inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups: the constitutively expressed lamin B and the developmentaly regulated lamin A.
      The best characterized isoforms of lamin binding protein LAP2 are LAP2α and LAP2β. LAP2β is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2α has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization. LAP2 has a unique COOH terminus from the other LAP2 isoforms. The COOH terminus of LAP2 binds Rb (Retinoblastoma) and is thought to play a role in cell cycle progression and differentiation.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% NaN3.
      Applications
      ApplicationAnti-LAP2α Antibody, clone 3A3 detects level of LAP2α & has been published & validated for use in WB & IF.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      Biological Information
      ImmunogenKLH conjugated synthetic peptide to C terminus region of human LAPα. This antibody detects LAP2α regardless of a naturally occurring Arginine to Cysteine mutation at position 690.
      Cloneclone 3A3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityHuman LAP2α. Does not cross react with mouse or rat LAP2α
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TMPO
      UniProt Number
      Molecular Weight76 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on lysates from K563 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-LAP2a, clone 3A3 - NG1513575 NG1513575

      References

      Reference overviewPub Med ID
      Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly.
      Crabbe, L; Cesare, AJ; Kasuboski, JM; Fitzpatrick, JA; Karlseder, J
      Cell reports  2  1521-9  2012

      Show Abstract
      23260663 23260663
      Evolution in quantum leaps: multiple combinatorial transfers of HPI and other genetic modules in Enterobacteriaceae.
      Armand Paauw,Maurine A Leverstein-van Hall,Jan Verhoef,Ad C Fluit
      PloS one  5  2010

      Show Abstract Full Text Article
      20084283 20084283