05-832 | Anti-LKB1 Antibody, clone 5c10

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RICC, WBMPurifiedMonoclonal Antibody
      Catalogue Number05-832
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-LKB1 Antibody, clone 5c10
      Product Information
      • Rat2 cell lysate
      PresentationProtein G Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% Sodium Azide, pH 7.4.
      ApplicationThis Anti-LKB1 Antibody, clone 5c10 is validated for use in IC, WB for the detection of LKB1.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 1-433 of human LKB1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes LKB1.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
      Gene Symbol
      • STK11
      • PJS
      • LKB1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
      COFACTOR: Magnesium or Manganese.
      SIZE: 433 amino acids; 48636 Da
      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
      TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.
      PTM: Phosphorylated by a cAMP-dependent protein kinase (By similarity).
      DISEASE: SwissProt: Q15831 # Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. & Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
      SIMILARITY: SwissProt: Q15831 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Molecular Weight55 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Rat2 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - 2428679 2428679
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) 2806556
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) 3017571
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - 1966938 1966938
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - 2287180 2287180
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - DAM1821098 DAM1821098
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - JBC1857731 JBC1857731
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) -2506416 2506416
      Anti-LKB1, clone 5c10 - 2044807 2044807
      Anti-LKB1, clone 5c10 - 27013 27013


      Reference overviewApplicationPub Med ID
      The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
      Nakada, Y; Stewart, TG; Peña, CG; Zhang, S; Zhao, N; Bardeesy, N; Sharpless, NE; Wong, KK; Hayes, DN; Castrillon, DH
      PloS one  8  e73449  2013

      Show Abstract
      Immunohistochemistry24086281 24086281
      Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
      Baas, A. F., et al
      Cell, 116:457-66 (2004)  2004

      Immunocytochemistry15016379 15016379
      Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
      Baas, A F, et al.
      EMBO J., 22: 3062-72 (2003)  2003

      12805220 12805220
      Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia
      Rambaldi, A., et al
      Leuk Lymphoma, 21:457-66 (1996)  1996

      Immunoblotting (Western)9172811 9172811

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      Life Science Research > Antibodies and Assays > Primary Antibodies