05-832 | Anti-LKB1 Antibody, clone 5c10

05-832
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-832
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-LKB1 Antibody, clone 5c10
      References
      Product Information
      FormatPurified
      Control
      • Rat2 cell lysate
      PresentationProtein G Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% Sodium Azide, pH 7.4.
      Applications
      ApplicationThis Anti-LKB1 Antibody, clone 5c10 is validated for use in IC, WB for the detection of LKB1.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 1-433 of human LKB1
      Clone5c10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes LKB1.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
      Gene Symbol
      • STK11
      • PJS
      • LKB1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
      COFACTOR: Magnesium or Manganese.
      SIZE: 433 amino acids; 48636 Da
      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
      TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.
      PTM: Phosphorylated by a cAMP-dependent protein kinase (By similarity).
      DISEASE: SwissProt: Q15831 # Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. & Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
      SIMILARITY: SwissProt: Q15831 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Molecular Weight55 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Rat2 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - 2428679 2428679
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) 2806556
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - 1966938 1966938
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - 2287180 2287180
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - DAM1821098 DAM1821098
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) - JBC1857731 JBC1857731
      Anti-LKB1, clone 5c10 (mouse monoclonal IgG) -2506416 2506416
      Anti-LKB1, clone 5c10 - 2044807 2044807
      Anti-LKB1, clone 5c10 - 27013 27013
      Anti-LKB1, clone 5c10 - 31781 31781

      References

      Reference overviewApplicationPub Med ID
      The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
      Nakada, Y; Stewart, TG; Peña, CG; Zhang, S; Zhao, N; Bardeesy, N; Sharpless, NE; Wong, KK; Hayes, DN; Castrillon, DH
      PloS one  8  e73449  2013

      Show Abstract
      Immunohistochemistry24086281 24086281
      Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
      Baas, A. F., et al
      Cell, 116:457-66 (2004)  2004

      Immunocytochemistry15016379 15016379
      Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
      Baas, A F, et al.
      EMBO J., 22: 3062-72 (2003)  2003

      12805220 12805220
      Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia
      Rambaldi, A., et al
      Leuk Lymphoma, 21:457-66 (1996)  1996

      Immunoblotting (Western)9172811 9172811

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      07-694 Anti-LKB1 Antibody Show Pricing & Availability
      09-478 Anti-phospho-LKB1 (Ser307) Antibody Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies