07-705 | Anti-LSD1/BHC110 Antibody

07-705
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-705
      ReplacesMABE545
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-LSD1/BHC110 Antibody
      Alternate Names
      • KDM1
      References
      Product Information
      FormatSerum
      Applications
      ApplicationUse Anti-LSD1/BHC110 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect LSD1/BHC110 also known as KDM1.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 47-66 (PAEV-GPGAVGERTPRKKEPP) of human BRAF-HDAC complex protein/Lysine-specific histone demethylase 1 (BHC110/LSD1).
      HostRabbit
      SpecificityRecognizes BHC110/LSD1
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternate splicing has been observed; however, not all transcript variants have been fully characterized.
      Gene Symbol
      • AOF2
      • LSD1
      • KIAA0601
      • BHC110
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O60341 # Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and tri- methylated 'Lys-4' of histone H3. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. May also demethylate 'Lys- 9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
      COFACTOR: FAD.
      SIZE: 852 amino acids; 92903 Da
      SUBUNIT: Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR).
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Ubiquitously expressed.
      DOMAIN: SwissProt: O60341 The SWIRN domain may act as an anchor site for a histone tail.
      SIMILARITY: Belongs to the flavin monoamine oxidase family. & Contains 1 SWIRM domain.
      Molecular Weight110kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies