05-206 | Anti-Laminin B2 Antibody, clone A5

05-206
50 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, IHCRPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-206
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Laminin B2 Antibody, clone A5
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.0
      Applications
      ApplicationAnti-Laminin B2 Antibody, clone A5 is an antibody against Laminin B2 for use in IP, IH.
      Key Applications
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesNot recommended for WB.
      Biological Information
      ImmunogenMurine EHS laminin
      Cloneclone A5
      HostRat
      SpecificityB2 chain laminin; does not cross-react with other basement membrane components or fibronectin
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LAMB2
      • S-laminin
      • LAMS
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P55268 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
      SIZE: 1798 amino acids; 195981 Da
      SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (S-laminin), laminin-4 (S- merosin), and laminin-7 (KS-laminin).
      SUBCELLULAR LOCATION: Secreted, extracellular space. Note=S- laminin is concentrated in the synaptic cleft of the neuromuscular junction.
      DOMAIN: SwissProt: P55268 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domains VI and IV are globular.
      DISEASE: SwissProt: P55268 # Defects in LAMB2 are the cause of Pierson syndrome [MIM:609049]; also known as microcoria-congenital nephrotic syndrome. Pierson syndrome is characterized by nephrotic syndrome with neonatal onset, diffuse mesangial sclerosis and eye abnormalities with microcoria as the leading clinical feature. Death usually occurs within the first weeks of life. Disease severity depends on the mutation type: nontruncating LAMB2 mutations may display variable phenotypes ranging from a milder variant of Pierson syndrome to isolated congenital nephrotic syndrome. & Defects in LAMB2 are a cause of congenital nephrotic syndrome [MIM:609049]. Congenital nephrotic syndrome constitutes a heterogeneous group of conditions having in common the disruption of normal glomerular permselectivity. Congenital nephrotic syndrome due to LAMB2 mutations may be associated with ocular abnormalities.
      SIMILARITY: Contains 13 laminin EGF-like domains. & Contains 1 laminin IV type B domain. & Contains 1 laminin N-terminal domain.
      Molecular Weight196 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated on unfixed, frozen monkey brain sections
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Laminin B2, clone A5 2475722
      Anti-Laminin B2, clone A5 (rat monoclonal IgG) - 2424760 2424760
      Anti-Laminin B2, clone A5 (rat monoclonal IgG) 2982395
      Anti-Laminin B2, clone A5 (rat monoclonal IgG) - 1993895 1993895
      Anti-Laminin B2, clone A5 - 11704 11704
      Anti-Laminin B2, clone A5 - 2044812 2044812
      Anti-Laminin B2, clone A5 - 2155404 2155404
      Anti-Laminin B2, clone A5 - 2289135 2289135
      Anti-Laminin B2, clone A5 - 28753 28753
      Anti-Laminin B2, clone A5 - DAM1601818 DAM1601818

      References

      Reference overviewApplicationPub Med ID
      The pre- and post-somatic segments of the human type I spiral ganglion neurons--structural and functional considerations related to cochlear implantation.
      Liu, W; Edin, F; Atturo, F; Rieger, G; Löwenheim, H; Senn, P; Blumer, M; Schrott-Fischer, A; Rask-Andersen, H; Glueckert, R
      Neuroscience  284  470-82  2015

      Show Abstract
      Immunohistochemistry25316409 25316409
      Macromolecular organization and fine structure of the human basilar membrane - RELEVANCE for cochlear implantation.
      Liu, W; Atturo, F; Aldaya, R; Santi, P; Cureoglu, S; Obwegeser, S; Glueckert, R; Pfaller, K; Schrott-Fischer, A; Rask-Andersen, H
      Cell and tissue research  360  245-62  2015

      Show Abstract
      25663274 25663274
      Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.
      Cosgrove, BD; Gilbert, PM; Porpiglia, E; Mourkioti, F; Lee, SP; Corbel, SY; Llewellyn, ME; Delp, SL; Blau, HM
      Nature medicine  20  255-64  2014

      Show Abstract
      24531378 24531378
      Immunohistochemical distribution of basement membrane proteins in the human inner ear from older subjects.
      Akira Ishiyama,Sarah E Mowry,Ivan A Lopez,Gail Ishiyama
      Hearing research  254  2009

      Show Abstract Full Text Article
      19348877 19348877
      Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
      Xunwei Wu,Shaohua Li,Anna Chrostek-Grashoff,Aleksandra Czuchra,Hannelore Meyer,Peter D Yurchenco,Cord Brakebusch
      Developmental dynamics : an official publication of the American Association of Anatomists  236  2007

      Show Abstract
      17849438 17849438
      Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo.
      Brockbank, EC; Bridges, J; Marshall, CJ; Sahai, E
      British journal of cancer  92  102-12  2005

      Show Abstract
      15597106 15597106
      Contributions of the LG modules and furin processing to laminin-2 functions
      Smirnov, S. P., et al
      J Biol Chem, 277:18928-37 (2002)  2002

      Immunocytochemistry11886875 11886875
      Distribution of individual components of basement membrane in human colon polyps and adenocarcinomas as revealed by monoclonal antibodies
      Ljubimov, A. V., et al
      Int J Cancer, 50:562-6 (1992)  1992

      Immunoprecipitation, Immunohistochemistry (Tissue)1371500 1371500
      Optimization of immunohistochemical techniques to detect extracellular matrix proteins in fixed skin specimens.
      Folkvord, J M, et al.
      J. Histochem. Cytochem., 37: 105-13 (1989)  1989

      Show Abstract
      Immunohistochemistry (Paraffin)2461979 2461979
      Basement membrane components produced by a mouse ascites teratocarcinoma TB24. Analysis with monoclonal and polyclonal antibodies.
      Ljubimov, A V, et al.
      Exp. Cell Res., 165: 530-40 (1986)  1986

      Show Abstract
      3522258 3522258

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies