04-268 | Anti-Lyn Antibody, clone 10A6.2

04-268
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, ChWBMAscitesMonoclonal Antibody
      Description
      Catalogue Number04-268
      Trade Name
      • Upstate
      DescriptionAnti-Lyn Antibody, clone 10A6.2
      Alternate Names
      • v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
      Background InformationLyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a member of the Src family of protein tyrosine kinases and is expressed primarily in hematopoietic cells and neural tissues. Lyn is involved in the regulation of cell activation by undergoing phosphorylation upon activation. Lyn activation triggers downstream signaling pathways that are mediated by Lyn phosphorylation of tyrosine residues of receptor proteins and recruitment and activation of other kinases including Syk, phospholipase Cγ2 (PLCγ2) and phosphatidyl inositol-3 kinase. Lyn also plays an important role in B cells as a key regulator of both positive and negative signals, thus acting to maintain the balance between activation and inhibition. Deregulation of this balance can result in severe pathological consequences such as autoimmune disease.
      References
      Product Information
      FormatAscites
      Control
      • A431 cell lysate
      PresentationMouse monoclonal IgG1κ ascites containing 0.05% sodium azide.
      Applications
      ApplicationAnti-Lyn Antibody, clone 10A6.2 is an antibody against Lyn for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: 1:500-1:1000 dilution of this lot detected Lyn in A431 cell lysate.
      Biological Information
      ImmunogenKLH conjugated linear peptide corresponding to the C-terminus of Lyn.
      EpitopeC-Terminus
      Clone10A6.2
      HostMouse
      SpecificityRecognizes the C-terminus of Lyn (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Chicken
      Species Reactivity NoteHuman.
      Predicted reactivity with mouse, rat and chicken based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • JTK8
      • Lyn
      • FLJ26625
      UniProt Number
      UniProt SummaryCATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family.
      SIMILARITY: Contains 1 SH2 domain.
      SIMILARITY: Contains 1 SH3 domain.
      SIMILARITY: Contains 1 protein kinase domain.
      Molecular Weight58 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Lyn, clone 10A6.2 - 2427470 2427470
      Anti-Lyn, clone 10A6.2 - NG1537595 NG1537595
      Anti-Lyn, clone 10A6.2 -2577333 2577333
      Anti-Lyn, clone 10A6.2 -2608406 2608406
      Anti-Lyn, clone 10A6.2 -2810617 2810617
      Anti-Lyn, clone 10A6.2 -2820733 2820733

      References

      Reference overviewApplicationPub Med ID
      USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.
      Sharma, N; Zhu, Q; Wani, G; He, J; Wang, QE; Wani, AA
      Cell cycle (Georgetown, Tex.)  13  106-14  2014

      Show Abstract
      Western Blotting24196443 24196443