07-394 | Anti-MAGE-D1/NRAGE Antibody

07-394
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WB, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-394
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MAGE-D1/NRAGE Antibody
      References
      Product Information
      FormatSerum
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, before the addition of glycerol to 30%
      Applications
      ApplicationAnti-MAGE-D1/NRAGE Antibody is an antibody against MAGE-D1/NRAGE for use in IP, WB, IH.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 53-295 of rat MAGE-D1/NRAGE
      HostRabbit
      SpecificityNRAGE/MAGE-D1
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
      Gene Symbol
      • MAGED1
      • PP2250
      • NRAGE
      • DLXIN-1
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y5V3 # Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.
      SIZE: 778 amino acids; 86161 Da
      SUBUNIT: Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity). Interacts with the p75 neurotrophin receptor.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF (By similarity).
      TISSUE SPECIFICITY: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
      SIMILARITY: SwissProt: Q9Y5V3 ## Contains 1 MAGE domain.
      Molecular Weight90-96 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in RIPA lysates from PC12 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-NRAGE/MAGE-D1 2474903
      Anti-NRAGE/MAGE-D1 (rabbit antiserum) 2903462
      Anti-NRAGE/MAGE-D1 (rabbit antiserum) 2879683
      Anti-NRAGE/MAGE-D1 - 24292 24292
      Anti-NRAGE/MAGE-D1 - DAM1776460 DAM1776460

      References

      Reference overviewPub Med ID
      NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.
      Salehi, Amir H, et al.
      J. Biol. Chem., 277: 48043-50 (2002)  2002

      Show Abstract
      12376548 12376548
      NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
      Salehi, A H, et al.
      Neuron, 27: 279-88 (2000)  2000

      Show Abstract
      10985348 10985348