04-580 | Anti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal

04-580
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IP, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-580
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MALT1/MLT1 (NT) Antibody, clone EP603Y, rabbit monoclonal
      Alternate Names
      • Mucosa-associated lymphoid tissue lymphoma translocation protein 1
      Background InformationMucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5).
      References
      Product Information
      FormatPurified
      PresentationBuffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
      Applications
      ApplicationAnti-MALT1/MLT1 (N-Term) Antibody, clone EP603Y detects level of MALT1/MLT1 (N-Term) & has been published & validated for use in FC, IP & WB.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Western Blotting
      Application NotesWB: 1:2,000
      Flow Cytometry: 1:30
      IP: 1:50
      Biological Information
      ImmunogenA synthetic peptide corresponding to residues in the N-term of human MALT1. This antibody is predicted to detect splice isoform 2 based on sequence analysis.
      CloneEP603Y
      HostRabbit
      SpecificityRecognizes Human MALT1/MLT1 (N-Term).
      Species Reactivity
      • Human
      Species Reactivity NoteHuman (positive control: Jurkat cell lysate)
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
      Gene Symbol
      • MALT1
      • paracaspase
      • MLT1
      • MLT
      • Paracaspase
      • DKFZp434L132
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UDY8 # Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity.
      SIZE: 824 amino acids; 92272 Da
      SUBUNIT: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.
      SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.
      TISSUE SPECIFICITY: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
      DISEASE: SwissProt: Q9UDY8 # A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
      SIMILARITY: SwissProt: Q9UDY8 ## Belongs to the peptidase C14 family. & Contains 1 death domain. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20 °C. Stable for 12 months from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-MALT1/MLT1 (N-Term.), clone EP603Y (Rabbit Monoclonal) - 2106908 2106908
      Anti-MALT1/MLT1 (N-Term.), clone EP603Y - DAM1548635 DAM1548635
      Anti-MALT1/MLT1 (N-Term.), clone EP603Y - TE0161990 TE0161990
      Anti-MALT1/MLT1 (N-Term.), clone EP603Y -2499514 2499514
      Anti-MALT1/MLT1 (N-Term.), clone EP603Y -2510392 2510392

      References

      Reference overviewPub Med ID
      Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO
      Zhou, Honglin, et al
      Nature, 427:167-71 (2004)  2004

      14695475 14695475
      Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway
      Lucas, P C, et al
      J Biol Chem, 276:19012-9 (2001)  2001

      11262391 11262391
      Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
      Uren, A G, et al
      Mol Cell, 6:961-7 (2000)  2000

      11090634 11090634
      The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
      Dierlamm, J, et al
      Blood, 93:3601-9 (1999)  1999

      10339464 10339464
      A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
      Akagi, T, et al
      Oncogene, 18:5785-94 (1999)  1999

      10523859 10523859