06-601 | Anti-MAPKAP Kinase 3 Antibody (3pK)

06-601
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIPShAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-601
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MAPKAP Kinase 3 Antibody (3pK)
      References
      Product Information
      FormatAffinity Purified
      Presentation50mM Tris-glycine, pH 7.4
      Applications
      ApplicationDetect the MAPKAP Kinase 3 protein using this Anti-MAPKAP Kinase 3 (3pK) validated for use in IP.
      Key Applications
      • Immunoprecipitation
      Application NotesWestern Blot is NOT recommended.
      Biological Information
      ImmunogenKLH/BSA-conjugated, synthetic peptide (KQAGSSSASQGCNNQG) corresponding to amino acids 368-382 of human MAPKAP Kinase 3
      HostSheep
      SpecificityMAPKAP K3; does not recognize MAPKAP K2
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
      Gene Symbol
      • MAPKAPK3
      • MAPKAP3
      • 3PK
      • MAPKAPK-3
      • 3pK
      • MAPKAP
      Purification MethodImmunoaffinity Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16644 # Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.
      SIZE: 382 amino acids; 42987 Da
      SUBUNIT: Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.
      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
      TISSUE SPECIFICITY: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.
      SIMILARITY: SwissProt: Q16644 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Molecular Weight42kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipitation kinase assay
      Sales RestrictionsThis sheep antibody cannot be distributed in the United States due to USDA regulations. For sales of this antibody outside the United States, please contact Millipore's European Support: E-mail: eurotechserv@millipore.com
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-MAPKAP Kinase 3 (3pK) - 15920 15920
      Anti-MAPKAP Kinase 3 (3pK) - 17976 17976

      References

      Reference overviewPub Med ID
      A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
      Clifton, A D, et al.
      FEBS Lett., 392: 209-14 (1996)  1996

      Show Abstract
      8774846 8774846