04-449 | Anti-MIP-1 β/CCL4 (CT) Antibody, rabbit monoclonal

04-449
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-449
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MIP-1 β/CCL4 (CT) Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      PresentationIn 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationThis Anti-MIP-1 β/CCL4 (C-term) Antibody is validated for use in WB for the detection of MIP-1 β/CCL4 (C-term).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic phosphor-peptide composed of residues at the C-terminus of human MIP-1 beta/CCL4.
      HostRabbit
      SpecificityRecognizes a region composed of residues at the C-terminus of human MIP-1 beta/CCL4.
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CCL4
      • 1-69
      • G-26
      • LAG-1
      • MGC126026
      • ACT2
      • Act-2
      • HC21
      • SCYA4
      • SIS-gamma
      • SCYA4L
      • MGC104418
      • H400
      • ACT-2
      • MGC126025
      • LAG1
      • MIP-1-beta
      • MIP1B
      • AT744.1
      • SCYA2
      • CCL4L
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P13236 # Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
      SIZE: 92 amino acids; 10212 Da
      SUBUNIT: Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1- beta(3-69).
      SUBCELLULAR LOCATION: Secreted.
      PTM: N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.
      SIMILARITY: SwissProt: P13236 ## Belongs to the intercrine beta (chemokine CC) family.
      Molecular Weight10 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-MIP-1 beta/CCL4 (C-term), Rabbit monoclonal - 0611046355 0611046355

      References

      Reference overviewPub Med ID
      Transcription-dependence of histone H3 lysine 27 trimethylation at the Arabidopsis polycomb target gene FLC.
      Diana Mihaela Buzas,Masumi Robertson,E Jean Finnegan,Chris A Helliwell
      The Plant journal : for cell and molecular biology  65  2011

      Show Abstract
      21276103 21276103
      Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity.
      Guan, Ennan, et al.
      J. Biol. Chem., 277: 32348-52 (2002)  2002

      Show Abstract
      12070155 12070155
      Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion
      Jenne, D and Stanley, K K
      EMBO J, 4:3153-7 (1985)  1985

      3004934 3004934