MABC607 | Anti-MTSS1 Antibody, clone 15C3.2

MABC607
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MkWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC607
      DescriptionAnti-MTSS1 Antibody, clone 15C3.2
      Alternate Names
      • Metastasis suppressor protein 1
      • Metastasis suppressor YGL-1
      • Missing in metastasis protein
      • MTSS1
      Background InformationMetastasis suppressor protein 1 (UniProt O43312; also known as Metastasis suppressor YGL-1, Missing in metastasis protein) is encoded by the MTSS1 (also known as KIAA0429, MIM) gene (Gene ID 9788) in human. MTSS1 is a scaffold protein that regulates cytoskeletal dynamics and actin polymerization. MTSS1 is also reported to bind Gli proteins or the Gli-Sufu complex and potentiate the transcription of effector genes of the sonic hedgehog signaling pathway. MTSS1 is down-regulated in many metastatic cancer cells compared with their non-metastatic counterparts. MTSS1 expression is shown to be inversely correlated with the prognosis of solid carcinomas of the breast, liver, and bladder.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect MTSS1 using this mouse monoclonal Anti-MTSS1 Antibody, clone 15C3.2, Cat. No. MABC607, validated for use in Western Blotting and Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MTSS1 in human colon and human spleen tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the C-terminal of human MTSS1.
      EpitopeC-terminal
      Clone15C3.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityThis clone is expected to react with all 4 spliced isoforms of human MTSS1.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Monkey
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MTSS1
      • KIAA0429
      • MIM
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~82 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in COS-1 cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected MTSS1 in 10 µg of COS-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications