06-815 | Anti-MYST family Antibody

06-815
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Yeast (S. cerevisiae)IP, WB, ICCRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-815
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-MYST family Antibody
      Alternate Names
      • K-Acetyltransferase
      • KAT
      References
      Product Information
      FormatPurified
      Presentation0.7M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% azide containing 30% glycerol
      Applications
      ApplicationUse Anti-MYST family Antibody (Rabbit Polyclonal Antibody) validated in IP, WB, ICC to detect MYST family also known as K-Acetyltransferase, KAT.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      Immunogenpeptide (C-ENKVGSPEKPLSDLG) corresponding to amino acids 331-345 of Yeast ESA1
      HostRabbit
      SpecificityYeast ESA1 and other mammalian MYST family members (MOZ, YBF2/SAS 3, SAS 2, Tip60, and MOF)
      IsotypeIgG
      Species Reactivity
      • Human
      • Yeast (S. cerevisiae)
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe MYST family of histone acetyltransferases, which includes MYST1, is named for the founding members MOZ (MYST3; MIM 601408), yeast YBF2 and SAS2, and TIP60 (HTATIP; MIM 601409). All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein-protein interactions and targeting transcriptional regulators to chromatin (Neal et al., 2000 [PubMed 10786633]).[supplied by OMIM]
      Gene Symbol
      • MYST1
      • FLJ14040
      • MOF
      • hMOF
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9H7Z6 # Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM.
      SIZE: 458 amino acids; 52403 Da
      SUBUNIT: Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/MYST1, MSL1/hampin, MSL2L1 and MSL3L1. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM through the chromodomain.
      SUBCELLULAR LOCATION: Nucleus.
      SIMILARITY: SwissProt: Q9H7Z6 ## Belongs to the MYST (SAS/MOZ) family. & Contains 1 C2HC-type zinc finger. & Contains 1 chromo domain.
      Molecular Weightmultiple
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from Jurkat cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-MYST family - 17603 17603

      References

      Reference overviewApplicationPub Med ID
      F-actin-dependent insolubility of chromatin-modifying components.
      Andrin, C; Hendzel, MJ
      The Journal of biological chemistry  279  25017-23  2004

      Show Abstract
      15082715 15082715
      Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns
      Craig, J. M., et al
      Hum Mol Genet, 12:3109-21 (2003)  2003

      Immunoblotting (Western)14519686 14519686
      ESA1 is a histone acetyltransferase that is essential for growth in yeast.
      Smith, E R, et al.
      Proc. Natl. Acad. Sci. U.S.A., 95: 3561-5 (1998)  1998

      Show Abstract
      9520405 9520405
      mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.
      Hilfiker, A, et al.
      EMBO J., 16: 2054-60 (1997)  1997

      Show Abstract
      9155031 9155031
      Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60.
      Yamamoto, T and Horikoshi, M
      J. Biol. Chem., 272: 30595-8 (1997)  1997

      Show Abstract
      9388189 9388189
      The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.
      Ehrenhofer-Murray, A E, et al.
      Genetics, 145: 923-34 (1997)  1997

      Show Abstract
      9093847 9093847

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies