CBL260-K | Anti-Macrophages, clone MAC387 (1mg)

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      Replacement Information
      Catalogue NumberCBL260-K
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Macrophages, clone MAC387 (1mg)
      OverviewThis product is intended for use by IVD manufacturers.
      Contact customer service for assistance: oem.reagents@emdmillipore.com
      Alternate Names
      • Anti-Macrophage
      Product Information
      PresentationThe monoclonal is presented at a concentration of 100μg(1ml) in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      ApplicationAnti-Macrophages Antibody, clone MAC387 detects level of Macrophages & has been published & validated for use in IH(P).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesSuitable for use on formalin-fixed paraffin sections. As seen with other macrophage markers CBL 260 is not totally macrophage specific and should be used in a panel of other antibodies.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman monocytes
      SpecificityRecognises the L1 or Calprotectin molecule, an intracytoplasmic antigen comprised of a 12kD a- chain and a 14kDa β-chain. The antigen is expressed by granulocytes, monocytes, tissue macrophages, neutrophils and squamous mucosal epithelia.

      KNOWN SPECIES CROSS REACTIVITY: Cross reacts with baboon, cat, dog, guinea pig, horse, monkey, rabbit, rat and swine.

      FUSION PARTNER: NS1 myeloma cell line.
      Species Reactivity
      • Canine
      • Horse
      • Guinea Pig
      • Human
      • Monkey
      • Pig
      • Rat
      • Rabbit
      • Baboon
      • Feline
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
      Gene Symbol
      • S100A8
      • CFAG
      • Calgranulin-A
      • 60B8AG
      • MRP8
      • CGLA
      • L1Ag
      • MIF
      • MRP-8
      • MA387
      • CAGA
      • CP-10
      • NIF
      • P8
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05109 # Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses. May interact with components of the intermediate filaments in monocytes and epithelial cells.
      SIZE: 93 amino acids; 10835 Da
      SUBUNIT: Homodimer.
      SIMILARITY: SwissProt: P05109 ## Belongs to the S-100 family. & Contains 2 EF-hand domains.
      MISCELLANEOUS: Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material SizeBulk packaging. Please inquire.
      Transport Information
      Supplemental Information

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      Catalogue Number Description  
      CBL260 Anti-Macrophages Antibody, clone MAC387 Show Pricing & Availability

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