07-121 | Anti-Moesin Antibody

07-121
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-121
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Moesin Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
      Applications
      ApplicationThis Anti-Moesin Antibody is validated for use in WB for the detection of Moesin.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 401-413 of human Moesin (C-EALLQASRDQKKT)
      HostRabbit
      SpecificityMoesin
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMoesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement.
      Gene Symbol
      • MSN
      • Moesin
      • moesin
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P26038 # Probably involved in connections of major cytoskeletal structures to the plasma membrane.
      SIZE: 577 amino acids; 67820 Da
      SUBUNIT: In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity).
      TISSUE SPECIFICITY: In all tissues and cultured cells studied.
      PTM: Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures (By similarity).
      SIMILARITY: SwissProt: P26038 ## Contains 1 FERM domain.
      Molecular Weight78kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on HeLa, A431, Jurkat, HFF, Raji, 3T3, CTLL, L6 or PC-12 cell lysates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Moesin - 20094 20094
      Anti-Moesin - 2040529 2040529
      Anti-Moesin - DAM1413912 DAM1413912

      References

      Reference overviewApplicationPub Med ID
      Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
      Yang, H. S. and Hinds, P. W.
      Mol Cell, 11:1163-76 (2003)  2003

      Immunoblotting (Western), Immunoprecipitation12769842 12769842
      Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins.
      Maeda, M, et al.
      Oncogene, 18: 4788-97 (1999)  1999

      Show Abstract
      10490812 10490812
      Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable.
      Franck, Z, et al.
      J. Cell. Sci., 105 ( Pt 1): 219-31 (1993)  1993

      Show Abstract
      8360275 8360275

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies