MAB5680 | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody

MAB5680
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RFC, ICC, IHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB5680
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody
      Alternate Names
      • MOG
      Background InformationMyelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.
      References
      Product Information
      FormatPurified
      Control
      • brain lysate
      PresentationPurified in PBS with 0.05% NaN3.
      Applications
      ApplicationAnti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody is an antibody against Myelin Oligodendrocyte Glycoprotein (MOG) for use in FC, IC, IH & WB.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenRat cerebellar glycoproteins
      EpitopeThe antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG.
      Clone8-18C5
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityMembane associated region of MOG [Myelin oligodendrocyte glycoprotein].
      IsotypeIgG1
      Species Reactivity
      • Mouse
      • Rat
      Species Reactivity NoteMay cross react with human and bovine based on sequence similarity.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Purification MethodPurified immunoglobulin
      UniProt Number
      UniProt SummaryFUNCTION: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication.
      SUBUNIT: May form homodimers.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.
      DEVELOPMENTAL STAGE: A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination.
      SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
      SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).
      Molecular Weight28 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-MOG, Clone 8-18C5 - 2116701 2116701
      Anti-MOG, Clone 8-18C5 - 2146016 2146016
      Anti-MOG, Clone 8-18C5 - 2366606 2366606
      Anti-MOG, Clone 8-18C5 - NG2452527 NG2452527
      Anti-MOG, Clone 8-18C5 - 1975956 1975956
      Anti-MOG, Clone 8-18C5 - 2020314 2020314
      Anti-MOG, Clone 8-18C5 - 2224500 2224500
      Anti-MOG, Clone 8-18C5 - 2291701 2291701
      Anti-MOG, Clone 8-18C5 - 2491187 2491187
      Anti-MOG, Clone 8-18C5 - JBC1793804 JBC1793804

      References

      Reference overviewPub Med ID
      Oligodendroglial maturation is dependent on intracellular protein shuttling.
      Göttle, P; Sabo, JK; Heinen, A; Venables, G; Torres, K; Tzekova, N; Parras, CM; Kremer, D; Hartung, HP; Cate, HS; Küry, P
      The Journal of neuroscience : the official journal of the Society for Neuroscience  35  906-19  2015

      Show Abstract
      25609610 25609610
      Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures.
      Pritchard, AJ; Mir, AK; Dev, KK
      PloS one  9  e99444  2014

      Show Abstract
      24911000 24911000
      Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
      Najm, FJ; Lager, AM; Zaremba, A; Wyatt, K; Caprariello, AV; Factor, DC; Karl, RT; Maeda, T; Miller, RH; Tesar, PJ
      Nature biotechnology  31  426-33  2013

      Show Abstract
      23584611 23584611
      M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.
      Miron, VE; Boyd, A; Zhao, JW; Yuen, TJ; Ruckh, JM; Shadrach, JL; van Wijngaarden, P; Wagers, AJ; Williams, A; Franklin, RJ; ffrench-Constant, C
      Nature neuroscience  16  1211-8  2013

      Show Abstract
      23872599 23872599

      Technical Info

      Title
      Derivation of oligodendrocyte progenitor cells from a human neural stem cell line

      Newsletters / Publications

      Title
      Cellutions - The newsletter for Cell Biology Researchers Volume 3: 2011