CBL431 | Anti-N-Myc Antibody, clone IA8

CBL431
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL431
      ReplacesCBL437
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-N-Myc Antibody, clone IA8
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationAnti-N-Myc Antibody, clone IA8 is a high quality Mouse Monoclonal Antibody for the detection of N-Myc & has been validated in WB & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern blotting on detergent lysates from cells expressing N-myc.

      Immunohistochemical studies of N-myc on frozen sections.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman N-myc sequence 334-343 + Cys.
      CloneIA8
      HostMouse
      SpecificityThe antibody reacts with a major peptide-blockable band at 62-64 kDa on western blots.
      IsotypeIgG2b
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq].
      Gene Symbol
      • MYCN
      • NMYC
      • N-Myc
      • BHLHE37
      UniProt Number
      UniProt SummaryFUNCTION: May function as a transcription factor.
      SIZE: 464 amino acids; 49561 Da
      SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1.
      SUBCELLULAR LOCATION: Nucleus.
      DEVELOPMENTAL STAGE: Expressed during fetal development.
      DISEASE: Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
      Defects in MYCN are the cause of Feingold syndrome; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
      Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence.
      SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN N-MYC -2576440 2576440
      MOUSE ANTI-HUMAN N-MYC -2608152 2608152
      MOUSE ANTI-HUMAN N-MYC -2705070 2705070
      MOUSE ANTI-HUMAN N-MYC MONOCLONAL ANTIBODY - 2108489 2108489
      MOUSE ANTI-HUMAN N-MYC MONOCLONAL ANTIBODY - 2188473 2188473
      MOUSE ANTI-HUMAN N-MYC MONOCLONAL ANTIBODY - 2193218 2193218
      MOUSE ANTI-HUMAN N-MYC MONOCLONAL ANTIBODY - 2314784 2314784

      References

      Reference overviewPub Med ID
      What is the value of bcl-2 protein detection for histopathologists?
      Pezzella, F and Gatter, K
      Histopathology, 26: 89-93 (1995)  1995

      7713489 7713489
      A sensitive and quantitative enzyme-linked immunosorbence assay for the c-myc and N-myc oncoproteins.
      Moore, J P, et al.
      Oncogene Res., 2: 65-80 (1987)  1987

      Show Abstract
      3333275 3333275

      Data Sheet

      Title
      Anti-N-myc, clone IA8 - Data Sheet

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies