06-1022 | Anti-NET34 Antibody

06-1022
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1022
      DescriptionAnti-NET34 Antibody
      Alternate Names
      • solute carrier family 39 (zinc transporter), member 14
      • LIV-1 subfamily of ZIP zinc transporter 4
      • solute carrier family 39 (metal ion transporter), member 14
      • Zrt-, Irt-like protein 14
      • Zrt- and Irt-like protein 14
      • zinc transporter ZIP14
      • Solute carrier family 39 member 14
      Background InformationNET34, more commonly known as as Zinc transporter ZIP14, or Zrt/Irt-like protein 14 is a membrane protein. Data suggests this protein functions as a zinc influx transporter and may also be able to transport iron. Three isoforms of this protein have been described.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEK293T cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-NET34 Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect NET34 also known as LIV-1 subfamily of ZIP zinc transporter 4, Solute carrier family 39 member 14.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected NET34 in HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human NET 34 at the extracellular domain.
      EpitopeExtracellular domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes NET34 at the extracellular domain.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with human and mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryZinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM].
      Gene Symbol
      • SLC39A14
      • LZT-Hs4
      • NET34
      • ZIP14
      • ZIP-14
      • cig19
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: May be able to transport iron (By similarity). Acts as a zinc-influx transporter.

      SUBUNIT STRUCTURE: Homotrimer.

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein Potential. Cell projection › lamellipodium. Note: Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae.

      TISSUE SPECIFICTY: Ubiquitously expressed, with increased expression in liver, pancreas, fetal liver, thyroid gland, left and right ventricle, right atrium and fetal heart. Weakly expressed in spleen, thymus, and peripheral blood leukocytes.

      SEQUENCE SIMILARITIES: Belongs to the ZIP transporter (TC 2.A.5) family. (View classification)

      SEQUENCE CAUTION: The sequence BAA06685.1 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight ~83 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293T cell lysate.

      Western Blot Analysis: 4 µg/mL of this antibody detected NET34 on 10 µg of HEK293T cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications