06-1025 | Anti-NET39 Antibody

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Catalogue Number06-1025
      DescriptionAnti-NET39 Antibody
      Alternate Names
      • phosphatidic acid phosphatase type 2 domain containing 3
      • chromosome 9 open reading frame 67
      • probable lipid phosphate phosphatase PPAPDC3
      • Phosphatidic acid phosphatase type 2 domain-containing protein 3
      Background InformationNET39 (nuclear envelope transmembrane protein 39) also known as Probable lipid phosphate phosphatase PPAPDC3, has been shown to play a part in regulation of signaling and gene expression. By effecting mTOR signaling, NET39 has a negative regulatory effect on myoblast differentiation. It is predominantly expressed in cardiac and skeletal muscle. During myoblast differentiation, NET39 is highly upregulated. NET39 has been found to be an important part of regulation for myogenesis and might also be involved in muscle homeostasis.
      Product Information
      FormatAffinity Purified
      • Rat liver tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationAnti-NET39 Antibody is a Rabbit Polyclonal Antibody for detection of NET39 has been validated in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected NET39 in A431 and HeLa cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human NET39 at the cytoplasmic domain.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThis antibody recognizes NET39 at the cytoplasmic domain.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Species Reactivity NoteDemonstrated to react with human, mouse, and rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PPAPDC3
      • NET39
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).

      SUBUNIT STRUCTURE: Homo and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).

      SUBCELLULAR LOCATION: Nucleus envelope. Endoplasmic reticulum membrane. Membrane; Multi-pass membrane protein. Note: Both the N- and C-terminal are exposed to the cytoplasm/nucleoplasm (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the PA-phosphatase related phosphoesterase family.

      SEQUENCE CAUTION: The sequence CAI16274.1 differs from that shown. Reason: Erroneous gene model prediction.
      Molecular Weight ~ 29 kDa observed. The band at ~23 kDa is uncharacterized, but may represent a possible isoform of this protein . (Malik, P., et al. (2010).
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat liver tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected NET39 on 10 µg of rat liver tissue lysate. Note: Western blot performed without Tween.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      Anti-NET39 - NRG1818958 NRG1818958


      Reference overviewPub Med ID
      Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.
      Zuleger, N; Boyle, S; Kelly, DA; de las Heras, JI; Lazou, V; Korfali, N; Batrakou, DG; Randles, KN; Morris, GE; Harrison, DJ; Bickmore, WA; Schirmer, EC
      Genome biology  14  R14  2013

      Show Abstract
      23414781 23414781