06-1344 | Anti-NLRP13 Antibody

06-1344
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1344
      DescriptionAnti-NLRP13 Antibody
      Alternate Names
      • NLR family, pyrin domain containing 13
      • Nucleotide-binding oligomerization domain protein 14
      • NACHT, leucine rich repeat and PYD containing 13
      • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13
      • NACHT, LRR and PYD containing protein 13
      • NACHT, LRR and PYD domains-containing protein 13
      Background InformationNLRP13, also known as NALP13, is a member of the NALP family of cytoplasmic proteins. NALPs have been associated with activating caspase-1 using toll-like receptors (TLRs) during the immune response. The specific function of NLRP13 is unknown.
      References
      Product Information
      FormatAffinity Purified
      Control
      • C2C12 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-NLRP13 Antibody detects level of NLRP13 & has been published & validated for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a previous lot detected NLRP13 in NIH/3T3 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human NLRP13.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySummary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM].
      Gene Symbol
      • NOD14
      • NALP13
      • PAN13
      • NLRP13
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Involved in inflammation Potential.

      SEQUENCE SIMILARITIES: Belongs to the NLRP family.

      Contains 1 DAPIN domain.

      Contains 7 LRR (leucine-rich) repeats.

      Contains 1 NACHT domain.
      Molecular Weight ~119 kDa observed. An uncharacterized band appears at ~90 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in C2C12 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected NLRP13 on 10 µg of C2C12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications