05-369X-555 | Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 555

05-369X-555
25 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ca, H, M, Mk, Po, R, Rb, Sh, XnFC, IF, WBMAlexaFluor®555Monoclonal Antibody
      Description
      Catalogue Number05-369X-555
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 555
      References
      Product Information
      FormatAlexaFluor®555
      Control
      • Included Negative Control: Catalog # 16-239, Alexa Fluor® 555-conjugated Normal Mouse IgG.
      Presentation25µg Alexa Fluor® 555-conjugated protein G purified mouse IgG1κ in 100µl of PBS containing 1% BSA, 0.05% Tween®-20, 0.05% sodium azide. Liquid at 4°C.
      Applications
      ApplicationDetect Na+/K+ ATPase α-1 using this Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor 555 validated for use in FC, IF & WB.
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Western Blotting
      Biological Information
      ImmunogenPurified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla.
      CloneC464.6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificitySpecific for the α-1 subunit isoform.
      IsotypeIgG1
      Species Reactivity
      • Canine
      • Human
      • Mouse
      • Monkey
      • Pig
      • Rat
      • Rabbit
      • Sheep
      • Xenopus
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.
      Gene Symbol
      • ATP1A3
      • MGC13276
      • RDP
      • IIIsubunit).
      • DYT12
      • +K
      • Na
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
      SIZE: 1013 amino acids; 111749 Da
      SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.
      SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.
      Molecular Weight113 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunoblot Analysis: 2µg/ml of this lot detected α-1 subunit in 40μg of rat brain microsomal preparation.

      Immunocytochemistry: 2µg/ml of this lot showed positive immunostaining for α-1 subunit in Colo 205 cells.

      Flow Cytometry: 0.2μg of this lot detected α-1 subunit in fixed NCI H292 cells (see data).
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsDo Not Freeze. Do not store the material diluted. Stable for 1 year at 4°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing cap.
      Packaging Information
      Material Size25 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Na+/K+ ATPase #945;-1, clone C464.6, Alexa Fluor#174; 555 conjugate (mouse monoclonal IgG1#954;) - 2113340 2113340
      Anti-Na+/K+ ATPase #945;-1, clone C464.6, Alexa Fluor#174; 555 conjugate (mouse monoclonal IgG1#954;) - 2121956 2121956
      Anti-Na+/K+ ATPase #945;-1, clone C464.6, Alexa Fluor#174; 555 conjugate - 2056623 2056623
      Anti-Na+/K+ ATPase -1, clone C464.6, Alexa Fluor#174; 555 conjugate (mouse monoclonal IgG1) - DAM1408966 DAM1408966
      Anti-Na+/K+ ATPase -1, clone C464.6, Alexa Fluor#174; 555 conjugate - 2036871 2036871
      Anti-Na+/K+ ATPase -1, clone C464.6, Alexa Fluor#174; 555 conjugate - 2045873 2045873
      Anti-Na+/K+ ATPase -1, clone C464.6, Alexa Fluor® 555 conjugate (mouse monoclonal IgG1) - 2322509 2322509
      Anti-Na+/K+ ATPase alpha;-1, clone C464.6, Alexa Fluorreg; 555 conjugate - D6D031 D6D031
      Anti-Na+/K+ ATPase α-1, clone C464.6, Alexa Fluor® 2455747
      Anti-Na+/K+ ATPase α-1, clone C464.6, Alexa Fluor® 555 conjugate -2780426 2780426

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      16-243 Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 488 Show Pricing & Availability

      Alternative Format

      Catalogue Number Description  
      05-369 Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6 Show Pricing & Availability
      16-243 Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 488 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies