06-172 | Anti-Na+/K+ ATPase α-3 Antibody

06-172
125 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHC, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-172
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Na+/K+ ATPase α-3 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-HCl, pH 7.2, containing 0.02% sodium azide
      Applications
      ApplicationAnti-Na+/K+ ATPase α-3 Antibody detects level of Na+/K+ ATPase α-3 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Biological Information
      ImmunogenFusion protein derived the alpha 3 subunit containing residues 320-514
      HostRabbit
      SpecificityNa+/K+ ATPase α-3
      IsotypeIgG
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.
      Gene Symbol
      • ATP1A3
      • MGC13276
      • RDP
      • IIIsubunit).
      • DYT12
      • +K
      • Na
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
      SIZE: 1013 amino acids; 111749 Da
      SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.
      SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.
      Molecular Weight112kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on brain microsomal preparations
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size125 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Na<sup>+</sup>/K<sup>+</sup> ATPase alpha;-3 - 12849 12849
      Anti-Rat Na,K-ATPase alpha 3 fusion protein (isoform specific) -2479958 2479958

      References

      Reference overviewApplicationPub Med ID
      Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons.
      Edwards, IJ; Bruce, G; Lawrenson, C; Howe, L; Clapcote, SJ; Deuchars, SA; Deuchars, J
      The Journal of neuroscience : the official journal of the Society for Neuroscience  33  9913-9  2013

      Show Abstract
      Western Blotting23761886 23761886
      Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat.
      Arakaki, X; McCleary, P; Techy, M; Chiang, J; Kuo, L; Fonteh, AN; Armstrong, B; Levy, D; Harrington, MG
      Fluids and barriers of the CNS  10  14  2013

      Show Abstract
      23497725 23497725
      Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.
      Clapcote, SJ; Duffy, S; Xie, G; Kirshenbaum, G; Bechard, AR; Rodacker Schack, V; Petersen, J; Sinai, L; Saab, BJ; Lerch, JP; Minassian, BA; Ackerley, CA; Sled, JG; Cortez, MA; Henderson, JT; Vilsen, B; Roder, JC
      Proceedings of the National Academy of Sciences of the United States of America  106  14085-90  2009

      Show Abstract
      19666602 19666602
      Stretch receptor-associated expression of alpha 3 isoform of the Na+, K+-ATPase in rat peripheral nervous system
      Dobretsov, M., et al
      Neuroscience, 116:1069-80 (2003)  2003

      Immunoblotting (Western)12617948 12617948
      Neurons and astroglia express distinct subsets of Na,K-ATPase alpha and beta subunits.
      Cameron, R, et al.
      Brain Res. Mol. Brain Res., 21: 333-43 (1994)  1994

      Show Abstract
      8170354 8170354
      Differential expression and enzymatic properties of the Na+,K(+)-ATPase alpha 3 isoenzyme in rat pineal glands.
      Shyjan, A W, et al.
      Proc. Natl. Acad. Sci. U.S.A., 87: 1178-82 (1990)  1990

      Show Abstract
      2153972 2153972

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies