05-557 | Anti-Notch 1 Antibody, clone 8G10

05-557
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RFC, ICC, WBSHmCulture SupernatantMonoclonal Antibody
      Description
      Catalogue Number05-557
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Notch 1 Antibody, clone 8G10
      Background InformationThe notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).
      References
      Product Information
      FormatCulture Supernatant
      Control
      • C2C12 cell lysate, breast, colon carcinoma
      PresentationCell Culture supernatant
      Applications
      ApplicationDetect Notch 1 with Anti-Notch 1 Antibody, clone 8G10 (Syrian Hamster Monoclonal Antibody), that has been shown to work in FC, ICC & WB.
      Key Applications
      • Flow Cytometry
      • Immunocytochemistry
      • Western Blotting
      Biological Information
      ImmunogenResidues 1299-1492 of murine notch 1
      Clone8G10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostSyrian Hamster
      SpecificityRecognizes Notch 1.
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NOTCH1
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight300 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on mouse C2C12 muscle myoblast cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Notch 1, clone 8G10 (syrian hamster monoclonal IgG) - 1988742 1988742
      Anti-Notch 1, clone 8G10 (syrian hamster monoclonal IgG) - 2091901 2091901
      Anti-Notch 1, clone 8G10 (syrian hamster monoclonal IgG) - 2324389 2324389
      Anti-Notch 1, clone 8G10 (syrian hamster monoclonal IgG) - JBC1913131 JBC1913131
      Anti-Notch 1, clone 8G10 - 20064 20064
      Anti-Notch 1, clone 8G10 - 24918 24918
      Anti-Notch 1, clone 8G10 - 2495646 2495646
      Anti-Notch 1, clone 8G10 - 32545 32545
      Anti-Notch 1, clone 8G10 - DAM1636066 DAM1636066
      Anti-Notch 1, clone 8G10 - DAM1661034 DAM1661034

      References

      Reference overviewApplicationPub Med ID
      Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma.
      Zaghloul, N; Hernandez, SL; Bae, JO; Huang, J; Fisher, JC; Lee, A; Kadenhe-Chiweshe, A; Kandel, JJ; Yamashiro, DJ
      International journal of oncology  34  401-7  2009

      Show Abstract
      Immunohistochemistry, Immunofluorescence19148474 19148474
      The human acid alpha-glucosidase gene is a novel target of the Notch-1/Hes-1 signaling pathway
      Yan, B., et al
      J Biol Chem, 277:29760-4 (2002)  2002

      Immunoblotting (Western)12065598 12065598

      FAQ

      QuestionAnswer
      What is the concentration of this antibody?We are not able to quantitate cultured supernatants.