MABS519 | Anti-P40 Antibody, clone 11F12.1

MABS519
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS519
      DescriptionAnti-P40 Antibody, clone 11F12.1
      Alternate Names
      • Tumor protein 63
      • p63
      • Chronic ulcerative stomatitis protein
      • CUSP
      • Keratinocyte transcription factor KET
      • Transformation-related protein 63
      • TP63
      • Tumor protein p73-like
      • p73L
      • p40
      • p51
      Background InformationP40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a transcriptional activator or repressor depending upon the target gene and the isoform involved. P40 has multiple isoforms. P40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover P40, developmentally, is required for proper limb formation. P40 is widely expressed in the adult and during development. Some isoforms, such as isoform 10 are primarily expressed in cancerous tissues while others are found only in normal tissues. Mutations in P40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome and Ankyloblepharon-ectodermal defects cleft lip/palate disorder and several more tragic disfiguring syndromes.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-P40 Antibody, clone 11F12.1 is an antibody against P40 for use in IHC (Paraffin) & western blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected P40 in human prostate and human kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human P40.
      Clone11F12.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TP63
      • KET
      • P63
      • P73H
      • P73L
      • TP73L
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~40 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SK-OV-3 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected P40 in 10 µg of SK-OV-3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies