528215 | Anti-PAI-1 Mouse mAb (MA-33B8)

528215
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityHostAntibody Type
      H, RbMMonoclonal Antibody

      Pricing & Availability

      Catalogue NumberAvailability Packaging Qty/Pack Price Quantity
      528215-100UG
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      Limited AvailabilityLimited Availability
      In Stock 
      Discontinued
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      Availability to be confirmed
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          Plastic ampoule 100 μg
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          Description
          OverviewRecognizes the ~50 kDa PAI-1 protein.
          Catalogue Number528215
          Brand Family Calbiochem®
          SynonymsAnti-Plasminogen Activator Inihibitor-1
          References
          ReferencesMontes, R., et al. 2000. Thromb. Haemost. 84, 65.
          Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
          Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
          Product Information
          FormLiquid
          FormulationIn 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
          PreservativeNone
          Applications
          Application ReferencesNeutralization Studies Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
          Key Applications Immunoblotting (Western Blotting)
          Neutralization Studies
          Application NotesImmunoblotting (10 µg/ml)
          Neutralization Studies (see application references)
          Application CommentsRapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
          Biological Information
          Immunogenhuman tPA-PAI-1 complex
          ImmunogenHuman
          CloneMA-33B8
          HostMouse
          Purity≥ 90% by SDS-PAGE
          IsotypeIgG
          Species Reactivity
          • Human
          • Rabbit
          Antibody TypeMonoclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          528215

          References

          Reference overview
          Montes, R., et al. 2000. Thromb. Haemost. 84, 65.
          Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
          Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-March-2009 JSW
          SynonymsAnti-Plasminogen Activator Inihibitor-1
          ApplicationImmunoblotting (10 µg/ml)
          Neutralization Studies (see application references)
          DescriptionPurified mouse monoclonal antibody. Recognizes the ~50 kDa PAI-1 protein.
          HostMouse
          Immunogen speciesHuman
          Immunogenhuman tPA-PAI-1 complex
          CloneMA-33B8
          IsotypeIgG
          Specieshuman, rabbit
          FormLiquid
          FormulationIn 100 mM NaCl, 50 mM sodium phosphate buffer, pH 7.4.
          Concentration Label Please refer to vial label for lot-specific concentration
          Purity≥ 90% by SDS-PAGE
          PreservativeNone
          CommentsRapidly inactivates PAI-1 (Plasminogen Activator Inhibitor-1) to the latent form. Like the native latent form, PAI-1 inactivated by antibody was protected from cleavage by elastase. Also shown to reduce renal fibrin deposits in a rabbit model of endotoxemia. Variables associated with assay conditions will dictate the proper working dilution.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesMontes, R., et al. 2000. Thromb. Haemost. 84, 65.
          Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.
          Debrock, S., and Declerck, P.J. 1997. Biochim. Biophys. Acta 1337, 257.
          Application referencesNeutralization Studies Verhamme, I., et al. 1999. J. Biol. Chem. 274, 17511.