06-902 | Anti-PAK3 Antibody, NT

06-902
200 µg  
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      Overview

      Replacement Information
      Replacement Information04-395 is the recommended replacement for Discontinued catalog number 06-902

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-902
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PAK3 Antibody, NT
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationDetect PAK3 using this Anti-PAK3 Antibody, NT validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide (MSDSLDNEEKPPA-C) corresponding to amino acids 1-13 of mouse PAK3
      HostRabbit
      SpecificityPAK3
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryPAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
      Gene Symbol
      • PAK3
      • OPHN3
      • PAK3beta
      • OTTHUMP00000062894
      • hPAK3
      • MRX47
      • MRX30
      • bPAK
      • oligophrenin-3
      • CDKN1A
      • PAK-3
      • Beta-PAK
      • Oligophrenin-3
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).
      COFACTOR: Magnesium (By similarity).
      SIZE: 559 amino acids; 62310 Da
      SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.
      TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
      PTM: Autophosphorylated when activated by CDC42/p21.
      DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.
      SIMILARITY: SwissProt: O75914 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
      Molecular Weight65kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from NIH 3T3 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PAK3, NT - 17670 17670
      Anti-PAK3, NT - 20628 20628

      References

      Reference overviewApplicationPub Med ID
      Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity.
      Briz, V; Zhu, G; Wang, Y; Liu, Y; Avetisyan, M; Bi, X; Baudry, M
      The Journal of neuroscience : the official journal of the Society for Neuroscience  35  2269-82  2015

      Show Abstract
      25653381 25653381
      LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.
      Seese, RR; Babayan, AH; Katz, AM; Cox, CD; Lauterborn, JC; Lynch, G; Gall, CM
      The Journal of neuroscience : the official journal of the Society for Neuroscience  32  7403-13  2012

      Show Abstract
      Western Blotting22623686 22623686
      Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.
      Chen, LY; Rex, CS; Babayan, AH; Kramár, EA; Lynch, G; Gall, CM; Lauterborn, JC
      The Journal of neuroscience : the official journal of the Society for Neuroscience  30  10977-84  2010

      Show Abstract
      20720104 20720104
      Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus.
      Rex, CS; Lin, CY; Kramár, EA; Chen, LY; Gall, CM; Lynch, G
      The Journal of neuroscience : the official journal of the Society for Neuroscience  27  3017-29  2007

      Show Abstract
      17360925 17360925
      Changes in synaptic morphology accompany actin signaling during LTP.
      Chen, LY; Rex, CS; Casale, MS; Gall, CM; Lynch, G
      The Journal of neuroscience : the official journal of the Society for Neuroscience  27  5363-72  2007

      Show Abstract
      17507558 17507558
      PAK3 mutation in nonsyndromic X-linked mental retardation.
      Allen, K M, et al.
      Nat. Genet., 20: 25-30 (1998)  1998

      9731525 9731525
      Identification of a mouse p21Cdc42/Rac activated kinase.
      Bagrodia, S, et al.
      J. Biol. Chem., 270: 22731-7 (1995)  1995

      7559398 7559398

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies