04-395 | Anti-PAK3 Antibody, rabbit monoclonal

04-395
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIF, IP, WB, IH(P)RbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-395
      Replaces06-902
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PAK3 Antibody, rabbit monoclonal
      Alternate Names
      • p21-activated Kinase 3
      • p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related)
      References
      Product Information
      FormatPurified
      Presentation100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-PAK3 Antibody, rabbit detects level of PAK3 & has been published & validated for use in IF, IP, WB, IH(P).
      Key Applications
      • Immunofluorescence
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to N-terminus of human PAK3 (p21-Activated Kinase 3).
      HostRabbit
      SpecificityRecognizes the N-terminus of PAK3.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryPAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
      Gene Symbol
      • PAK3
      • OPHN3
      • PAK3beta
      • OTTHUMP00000062894
      • hPAK3
      • MRX47
      • MRX30
      • bPAK
      • oligophrenin-3
      • CDKN1A
      • PAK-3
      • Beta-PAK
      • Oligophrenin-3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).
      COFACTOR: Magnesium (By similarity).
      SIZE: 559 amino acids; 62310 Da
      SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.
      TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
      PTM: Autophosphorylated when activated by CDC42/p21.
      DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.
      SIMILARITY: SwissProt: O75914 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
      Molecular Weight65 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PAK3, rabbit monoclonal - 0611045589 0611045589
      Anti-PAK3, rabbit monoclonal - JBC1371292 JBC1371292
      anti-PAK3, rabbit monoclonal 2485470
      anti-PAK3, rabbit monoclonal (Rabbit monoclonal IgG) - 2460919 2460919
      anti-PAK3, rabbit monoclonal - DAM1514040 DAM1514040
      anti-PAK3, rabbit monoclonal - NG1860456 NG1860456
      anti-PAK3, rabbit monoclonal - anti-PAK3, rabbit monoclonal ANTI-PAK3, RABBIT MO
      anti-PAK3, rabbit monoclonal -2561007 2561007

      References

      Reference overviewPub Med ID
      The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus
      Boda, Bernadett, et al
      J Neurosci, 24:10816-25 (2004)  2004

      15574732 15574732
      A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases
      Rousseau, Veronique, et al
      J Biol Chem, 278:3912-20 (2003)  2003

      12464619 12464619

      Related Products & Applications

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      Catalogue Number Description  
      06-902 Anti-PAK3 Antibody, NT Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies