CBL1337F | Anti-PECAM-1 Antibody, clone 390, FITC conjugated

CBL1337F
500 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, IHCRFITCMonoclonal Antibody
      Description
      Catalogue NumberCBL1337F
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-PECAM-1 Antibody, clone 390, FITC conjugated
      Alternate Names
      • CD31
      Background InformationPECAM-1 is a type I integral membrane glycoprotein, and a member of the immunoglobulin superfamily of cell surface receptors. PECAM-1 is constitutively expressed on the surface of endothelial cells where it is concentrated at cell junctions. PECAM-1 is also expressed at low levels on all leukocytes and platelets. Homotypic interaction of CD31 is important in cell-cell interaction, cell-matrix interaction and signal transduction.
      References
      Product Information
      FormatFITC
      PresentationPurified immunoglobulin conjugated to fluorescein. Liquid in in phosphate buffered saline containing 0.1% sodium azide.
      Applications
      ApplicationThis Anti-PECAM-1 Antibody, clone 390, FITC conjugated is validated for use in FC, IH for the detection of PECAM-1.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      Application NotesFlow Cytometry: = 1 μg per 10e6 cells in 100 μL volume

      Immunohistochemistry: acteone fixed frozen tissue sections.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenMouse leukocyte cell line 32D
      Clone390
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityCBL1337 recognizes mouse PECAM-1, a 130-140 kDa type 1 integral membrane glycoprotein. This antibody has been shown to inhibit the aggregation of L cells transfected with a variant form of PECAM-1 (DeLisser, 1993).
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PECAM1
      • EndoCAM
      • GPIIA
      • PECAM-1
      • CD31
      • CD31/EndoCAM
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16284 # This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
      SIZE: 738 amino acids; 82536 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart.
      PTM: Phosphorylated on Ser and Tyr residues after cellular activation.
      SIMILARITY: SwissProt: P16284 ## Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2°-8°C for up to 12 months from date of receipt. DO NOT FREEZE.
      Packaging Information
      Material Size500 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED MONOCLONAL ANTIBODY - 2121745 2121745
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED MONOCLONAL ANTIBODY - 2420393 2420393
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED -2586489 2586489
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED -2668111 2668111
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED -2681263 2681263
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED -2689123 2689123
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED -2728367 2728367
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED -2728995 2728995
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED -2817170 2817170
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED MONOCLONAL ANTIBODY 2953965

      References

      Reference overviewPub Med ID
      Mechanoinduction of lymph vessel expansion.
      Planas-Paz, L; Strilić, B; Goedecke, A; Breier, G; Fässler, R; Lammert, E
      The EMBO journal  31  788-804  2012

      Show Abstract
      22157817 22157817
      In vivo optical molecular imaging of vascular endothelial growth factor for monitoring cancer treatment.
      Chang, SK; Rizvi, I; Solban, N; Hasan, T
      Clinical cancer research : an official journal of the American Association for Cancer Research  14  4146-53  2008

      Show Abstract
      18593993 18593993

      Data Sheet

      Title
      RAT ANTI-MOUSE PECAM-1 [CD31] FITC-CONJUGATED MONOCLONAL ANTIBODY

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      Alternative Format

      Catalogue Number Description  
      CBL1337 Anti-PECAM-1 Antibody, clone 390 Show Pricing & Availability

      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies