CBL468 | Anti-PECAM-1 Antibody, domains 3-6 of human PECAM-1, clone HC1/6

CBL468
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IHC, IH(P), IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL468
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-PECAM-1 Antibody, domains 3-6 of human PECAM-1, clone HC1/6
      Alternate Names
      • CD31
      References
      Product Information
      FormatPurified
      Control
      • Activated microglial cells
      PresentationProtein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
      Applications
      ApplicationAnti-PECAM-1 Antibody, domains 3-6 of human PECAM-1, clone HC1/6 is an antibody against PECAM-1 for use in FC, IH, IH(P) & IP.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      Application NotesStudies of the role of CD31 in leucocyte migration into inflammatory sites and in the process of angiogenesis

      This antibody will stain frozen tissue sections

      Suitable for immunoprecipitation studies

      Suitable for flow cytometry either indirectly or directly when labelled with FITC or R-PE

      Suitable for use on formalin fixed paraffin embedded sections after protease pre-treatment.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPMA - treated U937 cells
      Epitopedomains 3-6 of human PECAM-1
      CloneHC1/6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with a 130-140 kDa transmembranous glycoprotein that is expressed widely amongst cells of the vascular compartment. CD31 is expressed on platelets, cultured endothelial cells, monocytes, normal tissue macrophages in tonsil, lung and kidney as well as in skin biopsies from conditions such as sarcoidosis and lepromatous leprosy.
      FUSION PARTNER: P3-x63Ag8.653 myeloma cell line
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PECAM1
      • EndoCAM
      • GPIIA
      • PECAM-1
      • CD31
      • CD31/EndoCAM
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16284 # This protein is a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions.
      SIZE: 738 amino acids; 82536 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Long isoform predominates all tissues examined, isoform Delta12 was detected only in trachea and isoform Delta14-15 only in lung, isoform Delta14 was detected in all tissues examined with the strongest expression in heart.
      PTM: Phosphorylated on Ser and Tyr residues after cellular activation.
      SIMILARITY: SwissProt: P16284 ## Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN CD31 MONOCLONAL ANTIBODY - 2366549 2366549
      MOUSE ANTI-HUMAN CD31 MONOCLONAL ANTIBODY - 2388906 2388906
      MOUSE ANTI-HUMAN CD31 MONOCLONAL ANTIBODY - 2433409 2433409
      MOUSE ANTI-HUMAN CD31 -2552266 2552266
      MOUSE ANTI-HUMAN CD31 -2557591 2557591
      MOUSE ANTI-HUMAN CD31 -2645966 2645966
      MOUSE ANTI-HUMAN CD31 -2669999 2669999
      MOUSE ANTI-HUMAN CD31 -2697529 2697529
      MOUSE ANTI-HUMAN CD31 -2716208 2716208
      MOUSE ANTI-HUMAN CD31 MONOCLONAL ANTIBODY - 2022037 2022037

      References

      Reference overviewPub Med ID
      Human glial-restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination.
      Walczak, P; All, AH; Rumpal, N; Gorelik, M; Kim, H; Maybhate, A; Agrawal, G; Campanelli, JT; Gilad, AA; Kerr, DA; Bulte, JW
      Glia  59  499-510  2011

      Show Abstract
      21264955 21264955
      Differential effects of HIF-1 inhibition by YC-1 on the overall outcome and blood-brain barrier damage in a rat model of ischemic stroke.
      Yan, J; Zhou, B; Taheri, S; Shi, H
      PloS one  6  e27798  2011

      Show Abstract
      22110762 22110762
      Gene array profile identifies collagen type XV as a novel human osteoblast-secreted matrix protein.
      Lisignoli, Gina, et al.
      J. Cell. Physiol., 220: 401-9 (2009)  2009

      Show Abstract
      19365806 19365806
      Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons.
      Obata, F; Tohyama, K; Bonev, AD; Kolling, GL; Keepers, TR; Gross, LK; Nelson, MT; Sato, S; Obrig, TG
      The Journal of infectious diseases  198  1398-406  2008

      Show Abstract
      18754742 18754742
      Molecular and functional aspects of PECAM-1/CD31
      DeLisser, H. M. et al.
      Immunol. Today, 15:490-495 (1994)  1994

      7945775 7945775
      Molecular characterization and functional analysis of the leukocyte surface protein CD31
      Stockinger, H. et al.
      J. Immunol., 145:3889-3897 (1990)  1990

      1700999 1700999
      Characterisation of a novel myeloid antigen regulated during differentiation of monocytic cells
      Carbanas, C. et al.
      Eur. J. Immunol., 19:1373-1378 (1989)  1989

      2506060 2506060

      Data Sheet

      Title
      MOUSE ANTI-HUMAN CD31 MONOCLONAL ANTIBODY

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      Alternative Packsize

      Catalogue Number Description  
      CBL468-K Anti-Pecam-1 Domains 3-6 Of Human Pecam-1 Clone Hc1/6 (0.1mg) Show Pricing & Availability

      Alternative Format

      Catalogue Number Description  
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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies