06-578 | Anti-PI4-Kinase β Antibody

06-578
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RICC, IP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-578
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PI4-Kinase β Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% Sodium Azide
      Applications
      ApplicationDetect PI4-Kinase β using this Anti-PI4-Kinase β Antibody validated for use in IC, IP & WB.
      Key Applications
      • Immunocytochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein corresponding to residues 410-537 of human PI 4-Kinase beta
      HostRabbit
      Specificitythe wortmannin-sensitive human PI 4-Kinase beta
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PIK4CB
      • PI4KIIIbeta
      • PI4K-beta
      • PI4Kbeta
      • NPIK
      • PI4K-BETA
      • PI4KB
      • PI4K92
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UBF8 # Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation.
      SIZE: 816 amino acids; 91379 Da
      SUBCELLULAR LOCATION: Intracytoplasmic membrane. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex.
      TISSUE SPECIFICITY: Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver.
      SIMILARITY: SwissProt: Q9UBF8 ## Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. & Contains 1 PI3K/PI4K domain.
      Molecular Weight~92 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot on RIPA lysates of Jurkat cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PI4-Kinase #226; - DAM1644558 DAM1644558
      Anti-PI4-Kinase #946; (rabbit polyclonal IgG) - 2149488 2149488
      Anti-PI4-Kinase #946; (rabbit polyclonal IgG) - DAM1810811 DAM1810811
      Anti-PI4-Kinase B (rabbit polyclonal IgG) 2906305
      Anti-PI4-Kinase b (rabbit polyclonal IgG) - 2283840 2283840
      Anti-PI4-Kinase b (rabbit polyclonal IgG) - DAM1749929 DAM1749929
      Anti-PI4-Kinase b - DAM1576925 DAM1576925
      Anti-PI4-Kinase b - DAM1687539 DAM1687539
      Anti-PI4-Kinase b - DAM1780370 DAM1780370
      Anti-PI4-Kinase b - DAM1834025 DAM1834025

      References

      Reference overviewApplicationPub Med ID
      Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication.
      Berger, KL; Kelly, SM; Jordan, TX; Tartell, MA; Randall, G
      Journal of virology  85  8870-83  2011

      Show Abstract
      21697487 21697487
      Characterization of recombinant phosphatidylinositol 4-kinase beta reveals auto- and heterophosphorylation of the enzyme
      Zhao, X. H., et al
      J Biol Chem, 275:14642-8 (2000)  2000

      Kinase Assay10799551 10799551
      Overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase, inhibits biosynthetic delivery of an apical protein in polarized madin-darby canine kidney cells
      Weisz, O. A., et al
      J Biol Chem, 275:24341-7 (2000)  2000

      Immunoblotting (Western)10825156 10825156
      Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.
      Meyers, R and Cantley, L C
      J. Biol. Chem., 272: 4384-90 (1997)  1997

      Show Abstract
      9020160 9020160
      Subcellular locations of phosphatidylinositol 4-kinase isoforms
      Wong, K., et al
      J Biol Chem, 272:13236-41 (1997)  1997

      Immunocytochemistry9148941 9148941
      A simple method to generate single-stranded probes for run-on transcription assays.
      Sell, C, et al.
      BioTechniques, 12: 692, 694 (1992)  1992

      1387540 1387540
      Bovine brain contains two types of phosphatidylinositol kinase.
      Endemann, G, et al.
      Biochemistry, 26: 6845-52 (1987)  1987

      Show Abstract
      2827737 2827737

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies