05-164 | Anti-PLCβ-1 Antibody

05-164
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, M, RIPMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-164
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PLCβ-1 Antibody
      References
      Product Information
      FormatPurified
      Presentation100mM Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide
      Applications
      ApplicationDetect PLCβ-1 using this Anti-PLCβ-1 Antibody validated for use in IP.
      Key Applications
      • Immunoprecipitation
      Biological Information
      ImmunogenMixed monoclonal antibodies raised against purified bovine PLCβ-1
      HostMouse
      SpecificityPLCβ-1, also recognize the 100kDa and 41kDa fragments of PLCβ-1.1
      Isotypemixed IgGs
      Species Reactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • PLCB1
      • PLC-beta-1
      • PLC-154
      • PLC-I
      • KIAA0581
      • FLJ45792
      • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
      • PI-PLC
      • inositoltrisphosphohydrolase
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NQ66 # The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
      COFACTOR: Calcium.
      SIZE: 1216 amino acids; 138567 Da
      SIMILARITY: SwissProt: Q9NQ66 ## Contains 1 C2 domain. & Contains 1 PI-PLC X-box domain. & Contains 1 PI-PLC Y-box domain.
      MISCELLANEOUS: The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.
      Molecular Weight150 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoprecipition of PLCβ-1 from a bovine brain membrane preparation, subsequent immunoblotting performed by the antibody
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PLCb-1 (mixed mouse monoclonal IgGs) - 2106953 2106953
      Anti-PLCb-1 (mixed mouse monoclonal IgGs) - 2189935 2189935
      Anti-PLCb-1 (mixed mouse monoclonal IgGs) - JBC1940041 JBC1940041
      Anti-PLCb-1 - 2299567 2299567
      Anti-PLCbeta;-1 - 12495 12495
      Anti-PLCbeta;-1 - 18120 18120
      Anti-PLCbeta;-1 - 21578 21578
      Anti-PLCbeta;-1 - 25996 25996
      Anti-PLCβ-1 (mixed mouse monoclonal IgGs) - 2318774 2318774
      Anti-PLCβ-1 (mixed mouse monoclonal IgGs) - 2433377 2433377

      References

      Reference overviewApplicationPub Med ID
      Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance.
      Tomicic, MT; Aasland, D; Naumann, SC; Meise, R; Barckhausen, C; Kaina, B; Christmann, M
      Cancer research  74  5585-96  2014

      Show Abstract
      25125662 25125662
      Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.
      Christmann, M; Tomicic, MT; Aasland, D; Berdelle, N; Kaina, B
      Nucleic acids research  38  6418-32  2010

      Show Abstract
      20511593 20511593
      Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression.
      Fiume, Roberta, et al.
      FASEB J., 23: 957-66 (2009)  2009

      Show Abstract
      19028838 19028838
      Low level of sarcolemmal phosphatidylinositol 4,5-bisphosphate in cardiomyopathic hamster (UM-X7.1) heart.
      A Ziegelhoffer, P S Tappia, N Mesaeli, N Sahi, N S Dhalla, V Panagia
      Cardiovascular research  49  118-26  2001

      Show Abstract
      11121803 11121803
      Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril.
      P S Tappia, S Y Liu, S Shatadal, N Takeda, N S Dhalla, V Panagia
      The American journal of physiology  277  H40-9  1999

      Show Abstract
      10409180 10409180
      delta Opioid receptor subtypes activate inositol-signaling pathways in the production of antinociception.
      P Sánchez-Blázquez, J Garzón
      The Journal of pharmacology and experimental therapeutics  285  820-7  1998

      Show Abstract
      9580632 9580632
      Phospholipase C-beta1 is present in the botrysome, an intermediate compartment-like organelle, and Is regulated by visual experience in cat visual cortex
      Kind, P. C., et al
      J Neurosci, 17:1471-80 (1997)  1997

      Immunoprecipitation9006988 9006988
      A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus
      Liu, N., et al
      J Biol Chem, 271:355-60 (1996)  1996

      Immunoblotting (Western)8550586 8550586
      Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells
      Wolf, B. A., et al
      J Biol Chem, 270:4916-22 (1995)  1995

      Immunoblotting (Western)7876266 7876266
      Monoclonal antibodies to three phospholipase C isozymes from bovine brain.
      Suh, P G, et al.
      J. Biol. Chem., 263: 14497-504 (1988)  1988

      Show Abstract
      2459119 2459119