07-1381 Anti-PP6R3 Antibody

07-1381
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1381
      DescriptionAnti-PP6R3 Antibody
      Alternate Names
      • Serine/threonine-protein phosphatase 6 regulatory subunit 3
      • SAPS domain family member 3
      • Sporulation-induced transcript 4-associated protein SAPL
      Background InformationPP6R3 (protein Ser/Thr phosphatase 6 regulatory subunit 3), also known as SAPS3 is a regulatory subunit of protein phosphatase 6 which is important for cell survival and is associated with TOR signaling in yeast. PP6R3 has been implicated in the transition from G1 to the S phase of mitosis. The PP6R3 subunit is one of three human versions of SAPs which may also have a role to play in regulation of NF-kappaB.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-PP6R3 Antibody detects level of PP6R3 & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: 1:200 dilution of a representative lot detected PP6R3 in human kidney and human breast tissues.
      Biological Information
      ImmunogenHistidine-tagged-recombinant protein corresponding to human PP6R3.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySummary: Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM].
      Gene Symbol
      • PPP6R3
      • C11orf23
      • KIAA1558
      • PP6R3
      • SAPL
      • SAPS3
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Regulatory subunit of protein phospatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance.

      SUBUNIT STRUCTURE: Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and ANKRD28.

      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.

      TISSUE SPECIFICITY: Expressed in skeletal muscle, placenta, heart, pancreas, testis, brain, lung, liver, kidney, spleen, thymus, prostate, small intestine, colon and leukocytes.

      POST-TRANSLATIONAL MODIFICATION: Phosphorylated upon DNA damage, probably by ATM or ATR.

      SEQUENCE SIMILARITIES: Belongs to the SAPS family.

      SEQUENCE CAUTION: The sequence AAZ99639.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91978.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB13384.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB71396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
      Molecular Weight~130-140 kDa observed. UniProt entry describes 6 isoforms produced by alternative splicing ranging from 88.9 to 98.9 kDa.


      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 1:10,000 dilution of this antibody detected PP6R3 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PP6R3 - NRG1897804NRG1897804
      Anti-PP6R3 -26249742624974
      Anti-PP6R3 -27326002732600

      References

      Reference overviewPub Med ID
      Promising developments in targeted therapies for non-small-cell lung cancer.
      Desirée Hao,Manuel Hidalgo
      Clinical lung cancer  4  2002

      Show Abstract
      14653868 14653868