05-1570 | Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ELISA, IHC, FCRPurifiedMonoclonal Antibody
      Catalogue Number05-1570
      DescriptionAnti-PRDM1 (BLIMP-1) Antibody, clone 6D3
      Alternate Names
      • PR domain containing 1, with ZNF domain
      • PR-domain zinc finger protein 1
      • beta-interferon gene positive-regulatory domain I binding factor
      • Positive regulatory domain I-binding factor 1
      • PRDI-binding factor-1
      • Beta-interferon gene positive regulatory domain I-binding factor
      • B-lymphocyte-induced maturation protein 1
      • PR domain-containing protein 1
      • PRDI-binding factor 1
      • PR domain zinc finger protein 1
      Background InformationB-lymphocyte induced maturation protein (BLIMP-1) is a 100 kDa transcriptional repressor containing 1 DET domain and 4 C2H2-type zinc fingers. In the nucleus, BLIMP-1 is known to bind specifically with the Beta-interferon gene positive regulatory domain I (PRDI), and to interact with PRMT5. During B-cell differentiation, BLIMP-1 actively represses the transcription of the gene, c-myc, through binding its promoter and has been deemed a “master regulator” for terminal B-cell differentiation, as it is able to initiate the BCL1 cell developmental cascade.
      Product Information
      • HL-60 cell lysate
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationUse Anti-PRDM1 (BLIMP-1) Antibody, clone 6D3 (Rat Monoclonal Antibody) validated in WB, ELISA, IHC, FC to detect PRDM1 (BLIMP-1) also known as PR-domain zinc finger protein 1.
      Key Applications
      • Western Blotting
      • ELISA
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesELISA Analysis: A representative lot was used by an independent laboratory in ELISA. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.)

      Flow Cytometry Analysis: A representative lot was used by an independent laboratory in FC. (Kallies, A., et al. (2004). J Exp Med. 200(8):967-977.)
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse BLIMP-1.
      EpitopeRecognizes epitope located between amino acids 255-395 of BLIMP-1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityRecognizes BLIMP-1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BLIMP1
      • PRDM1
      • PRDI-BF1
      • BLIMP-1
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.

      SUBUNIT STRUCTURE: Interacts with PRMT5. Ref.5

      SUBCELLULAR LOCATION: Nucleus (By similarity).

      SEQUENCE SIMILARITIES: Contains 4 C2H2-type zinc fingers.

      Contains 1 SET domain.

      SEQUENCE CAUTION: The sequence AAI29802.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
      Molecular Weight~ 95 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HL-60 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected BLIMP-1 on 10 µg of HL-60 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information