07-2070-I | Anti-PRDM9 Antibody

07-2070-I
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-2070-I
      Replaces07-2070
      DescriptionAnti-PRDM9 Antibody
      Alternate Names
      • Histone-lysine N-methyltransferase PRDM9
      • PR domain zinc finger protein 9
      • PR domain-containing protein 9
      Background InformationHistone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Like other PR-domain-containing proteins, PRDM9 (also known as MEISETZ, or Meiosis-induced factor containing PR/SET domain and zinc-finger motif) is thought to be involved in transcriptional regulation. PRDM9/MEISETZ is a novel histone tri-methyltransferase that regulates meiosis-specific epigenesis. PRDM9/MEISETZ catalyses H3K4 trimethylation and activates transcription through its methylation activity. It contains a KRAB motif also found in SSX genes.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human seminiferous tubules tissue
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect PRDM9 using this rabbit polyclonal antibody, Anti-PRDM9 Antibody validated for use in IHC (Paraffin) & IP.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      Application NotesImmunohistochemistry Analysis: A 1:200 dilution from a representative lot detected PRDM9 in human pancreas tissue.
      Immunoprecipitation Analysis: A representative lot immunoprecipitated 10 µg of PRDM9 from human testis tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human PRDM9.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PRDM9
      • PFM6
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~103 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human seminiferous tubules tissue.

      Imunnohistochemistry Analysis: A 1:200 dilution of this antibody detected PRDM9 in human seminiferous tubules tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications