07-639 | Anti-PRMT7 Antibody

07-639
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-639
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PRMT7 Antibody
      References
      Product Information
      FormatPurified
      Presentation70% storage buffer (0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide) and 30% glycerol
      Applications
      ApplicationAnti-PRMT7 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of PRMT7 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide (KIFCSRANPTTGSVEWLEEDEHYD) corresponding to amino acids 2-25 of human Prmt7.
      HostRabbit
      SpecificityPRMT7
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteAlso known to cross-react with chimpanzee.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryArginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM]
      Gene Symbol
      • PRMT7
      • KIAA1933
      • FLJ10640
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NVM4 # Probably methylates the guanidino nitrogens of arginyl residues in some proteins (By similarity).
      SIZE: 692 amino acids; 78459 Da
      SIMILARITY: SwissProt: Q9NVM4 ## Belongs to the protein arginine N-methyltransferase family.
      Molecular Weight85kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot on RIPA lysates from HEK293 cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PRMT7 - 27097 27097
      Anti-PRMT7 -2791323 2791323

      References

      Reference overviewApplicationPub Med ID
      Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family.
      Herrmann, F; Pably, P; Eckerich, C; Bedford, MT; Fackelmayer, FO
      Journal of cell science  122  667-77  2009

      Show Abstract
      19208762 19208762
      PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity.
      Miranda, Tina Branscombe, et al.
      J. Biol. Chem., 279: 22902-7 (2004)  2004

      Show Abstract
      15044439 15044439
      Identification of new drug sensitivity genes using genetic suppressor elements: protein arginine N-methyltransferase mediates cell sensitivity to DNA-damaging agents.
      Gros, Laurent, et al.
      Cancer Res., 63: 164-71 (2003)  2003

      Show Abstract
      12517794 12517794
      A proteomic analysis of arginine methylated protein complexes
      Boisvert, F. M., et al
      Mol Cell Proteomics, 2:1319-30 (2003)  2003

      Immunoblotting (Western)14534352 14534352

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies