04-035 | Anti-PTEN Antibody, clone 6H2.1

04-035
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IP, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-035
      Replaces07-016
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PTEN Antibody, clone 6H2.1
      Background InformationThe protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.
      References
      Product Information
      FormatPurified
      PresentationProtein G purified mouse IgG in storage buffer containing PBS with 0.05% sodium azide.
      Applications
      ApplicationAnti-PTEN Antibody, clone 6H2.1 detects level of PTEN & has been published & validated for use in WB, IP, IH(P).
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenC-terminal 100 amino acids of PTEN
      EpitopeC-terminal region
      Clone6H2.1
      HostMouse
      Specificityrecognizes PTEN
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PTEN
      • MMAC1
      • TEP1
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight55 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated on HeLa cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-2 Receptor , clone 7G7/B6 -2775434 2775434
      Anti-PTEN, clone 6H2.1 - 2424483 2424483
      Anti-PTEN, clone 6H2.1 - 2455715 2455715
      Anti-PTEN, clone 6H2.1 - 1993873 1993873
      Anti-PTEN, clone 6H2.1 - 2038721 2038721
      Anti-PTEN, clone 6H2.1 - 2073180 2073180
      Anti-PTEN, clone 6H2.1 - 2189937 2189937
      Anti-PTEN, clone 6H2.1 - 2329127 2329127
      Anti-PTEN, clone 6H2.1 - DAM1682190 DAM1682190
      Anti-PTEN, clone 6H2.1 - DAM1713258 DAM1713258

      References

      Reference overviewApplicationPub Med ID
      PTEN signaling is required for the maintenance of spermatogonial stem cells in mouse, by regulating the expressions of PLZF and UTF1.
      Zhou, W; Shao, H; Zhang, D; Dong, J; Cheng, W; Wang, L; Teng, Y; Yu, Z
      Cell & bioscience  5  42  2015

      Show Abstract
      26221533 26221533
      Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development.
      Jones, A; Teschendorff, AE; Li, Q; Hayward, JD; Kannan, A; Mould, T; West, J; Zikan, M; Cibula, D; Fiegl, H; Lee, SH; Wik, E; Hadwin, R; Arora, R; Lemech, C; Turunen, H; Pakarinen, P; Jacobs, IJ; Salvesen, HB; Bagchi, MK; Bagchi, IC; Widschwendter, M
      PLoS medicine  10  e1001551  2013

      Show Abstract
      24265601 24265601
      Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.
      Anastasio, NC; Gilbertson, SR; Bubar, MJ; Agarkov, A; Stutz, SJ; Jeng, Y; Bremer, NM; Smith, TD; Fox, RG; Swinford, SE; Seitz, PK; Charendoff, MN; Craft, JW; Laezza, FM; Watson, CS; Briggs, JM; Cunningham, KA
      The Journal of neuroscience : the official journal of the Society for Neuroscience  33  1615-30  2013

      Show Abstract
      23345234 23345234
      BRCAness profile of sporadic ovarian cancer predicts disease recurrence.
      Wysham, WZ; Mhawech-Fauceglia, P; Li, H; Hays, L; Syriac, S; Skrepnik, T; Wright, J; Pande, N; Hoatlin, M; Pejovic, T
      PloS one  7  e30042  2012

      Show Abstract
      Immunocytochemistry22253870 22253870
      Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity.
      Baker, DJ; Jin, F; Jeganathan, KB; van Deursen, JM
      Cancer cell  16  475-86  2009

      Show Abstract
      Immunohistochemistry19962666 19962666

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      Title
      Western Blotting Tools