05-941 | Anti-PTPA Antibody, clone 5G3

05-941
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue Number05-941
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-PTPA Antibody, clone 5G3
      References
      Product Information
      FormatCulture Supernatant
      Applications
      ApplicationDetect PTPA using this Anti-PTPA Antibody, clone 5G3 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenFull length mouse phosphotyrosyl phosphatase activator protein (PTPA)
      Cloneclone 5G3
      HostMouse
      SpecificityPTPA
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryProtein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.
      Gene Symbol
      • PPP2R4
      • PR53
      • KIAA0044
      • PTPA
      • MGC2184
      • PP2A
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15257 # Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer in presence of ATP and Mg(2+) (in vitro).
      SIZE: 358 amino acids; 40668 Da
      SUBUNIT: Associates with PP2A heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A).
      TISSUE SPECIFICITY: Widely expressed.
      SIMILARITY: SwissProt: Q15257 ## Belongs to the PTPA-type PPIase family.
      Molecular Weight38kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot detecting PTPA in RIPA lysates from HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-PTPA, clone 5G3 - 2482230 2482230
      Anti-PTPA, clone 5G3 - 2542047 2542047
      Anti-PTPA, clone 5G3 - 30532 30532
      Anti-PTPA, clone 5G3 -2664257 2664257
      Anti-PTPA, clone 5G3 -2784675 2784675

      References

      Reference overviewPub Med ID
      PP2A: the expected tumor suppressor.
      Janssens, Veerle, et al.
      Curr. Opin. Genet. Dev., 15: 34-41 (2005)  2005

      Show Abstract
      15661531 15661531
      The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes.
      Zheng, Yin and Jiang, Yu
      Mol. Biol. Cell, 16: 2119-27 (2005)  2005

      Show Abstract
      15689491 15689491
      An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator.
      Longin, Sari, et al.
      Biochem. J., 380: 111-9 (2004)  2004

      Show Abstract
      14748741 14748741
      A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.
      Fellner, Thomas, et al.
      Genes Dev., 17: 2138-50 (2003)  2003

      Show Abstract
      12952889 12952889
      Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.
      Janssens, V and Goris, J
      Biochem. J., 353: 417-39 (2001)  2001

      Show Abstract
      11171037 11171037
      PTPA regulating PP2A as a dual specificity phosphatase.
      Janssens, V, et al.
      Methods Mol. Biol., 93: 103-15 (1998)  1998

      9664530 9664530