05-1361 | Anti-PURA Antibody, clone 2B7

05-1361
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1361
      DescriptionAnti-PURA Antibody, clone 2B7
      Alternate Names
      • transcriptional activator protein PUR-alpha
      • purine-rich element binding protein A
      • Purine-rich single-stranded DNA-binding protein alpha
      Background InformationPurine-rich element binding protein A, also known as PURA, is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
      References
      Product Information
      FormatPurified
      Control
      • A549 cell lysate
      PresentationPurified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-PURA Antibody, clone 2B7 (mouse monoclonal antibody) validated in WB to detect PURA also known as transcriptional activator protein PUR-alpha, Purine-rich single-str&ed DNA-binding protein alpha .
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to PURA.
      Clone2B7
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody detects PURA.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq].
      Gene Symbol
      • PUR-ALPHA
      • PUR1
      • PURALPHA
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.

      SUBUNIT STRUCTURE: Homodimer, heterodimer with PURB and heterotrimer with PURB and YBX1/Y-box protein 1 By similarity.

      SUBCELLULAR LOCATION: Nucleus.

      SEQUENCE SIMILARITIES: Belongs to the PUR DNA-binding protein family.

      Molecular Weight~35-37 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western blot on A549 cell lysate.

      Western Blot Analysis: 0.5-2 µg/mL of this antibody detected PURA in A549 cell lysate.

      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications