05-1109 | Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01

05-1109
1 mg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1109
      ReplacesCBL94
      DescriptionAnti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01
      Alternate Names
      • CD220 antigen
      • insulin receptor
      Background InformationPro-Insulin consists of the three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the Insulin molecule). From every molecule of Pro-Insulin, one molecule of Insulin plus one molecule of C-peptide are produced. C-peptide is released into the blood stream in equal amounts to Insulin.
      References
      Product Information
      FormatPurified
      Control
      • Human normal pancreas tissue
      PresentationMouse monoclonal IgG1 in phosphate buffered saline, pH7.4, and 15 mM sodium azide.
      Applications
      ApplicationThis Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01 is validated for use in IH(P) for the detection of Pro-Insulin C-Peptide.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenSynthetic C-peptide of human pro-insulin conjugated to bovine serum albumin.
      CloneC-PEP-01
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody C-PEP-01 reacts specifically with C-peptide, a part of the Pro-insulin molecule.
      IsotypeIgG1
      Species Reactivity
      • Human
      Species Reactivity NoteReacts with human. No cross-reactivity with Insulin or other peptide hormones or proteins was observed.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ILPR
      • IRDN
      • OTTHUMP00000011161
      • OTTHUMP00000011162
      • OTTHUMP00000196038
      • insulin
      • proinsulin
      Purification MethodSequential precipitation with caprylic acid and ammonium sulfate.
      UniProt Number
      UniProt SummaryFUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
      SEQUENCE SIMILARITIES: Belongs to the insulin family.
      SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
      Molecular WeightApprox. 12 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in normal human pancreas.
      Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected insulin in human normal pancreas tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C and use within 1 year from date of receipt.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Pro-Insulin C-Peptide, clone C-PEP-01 - 2430453 2430453
      Anti-Pro-Insulin C-Peptide, -2585775 2585775
      Anti-Pro-Insulin C-Peptide, -2586148 2586148
      Anti-Pro-Insulin C-Peptide, -2611648 2611648
      Anti-Pro-Insulin C-Peptide, -2611775 2611775
      Anti-Pro-Insulin C-Peptide, -2626026 2626026
      Anti-Pro-Insulin C-Peptide, -2649099 2649099
      Anti-Pro-Insulin C-Peptide, -2721692 2721692
      Anti-Pro-Insulin C-Peptide, clone C-PEP-01 - 1977635 1977635
      Anti-Pro-Insulin C-Peptide, clone C-PEP-01 - 2058967 2058967

      References

      Reference overviewPub Med ID
      Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells.
      Yamada, Mitsutoshi, et al.
      Nature, (2014)  2014

      Show Abstract
      24776804 24776804
      iPSC-derived β cells model diabetes due to glucokinase deficiency.
      Hua, H; Shang, L; Martinez, H; Freeby, M; Gallagher, MP; Ludwig, T; Deng, L; Greenberg, E; Leduc, C; Chung, WK; Goland, R; Leibel, RL; Egli, D
      The Journal of clinical investigation  123  3146-53  2013

      Show Abstract
      23778137 23778137

      Brochure

      Title
      Product Selection Guide - Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      05-1107 Anti-Insulin Antibody, clone CE9H9 Show Pricing & Availability
      05-1108 Anti-Insulin Antibody, clone1 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies