06-1103 | Anti-Protein patched homolog 2 Antibody

06-1103
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Ca, EqWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1103
      DescriptionAnti-Protein patched homolog 2 Antibody
      Alternate Names
      • patched (Drosophila) homolog 2
      • patched 2
      • patched homolog 2 (Drosophila)
      Background InformationProtein patched homolog 2 is a 180 - 200 kDa 12 transmembrane member of the Patched family that exists in a signal cascade with Sonic Hedgehog (SHH) and Smoothened (SMO). Protein patched homolog 2 and Smoothened form a membrane complex that serves as a receptor for Sonic Hedgehog (SHH). Protein patched homolog 2 is 1203 amino acids (aa) in length. It has two terminal cytoplasmic domains, one between aa 1 - 57, and a second between aa 1115 - 1203.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-Protein patched homolog 2 Antibody is an antibody against Protein patched homolog 2 for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blot (SNAP ID) Analysis: 4 µg/mL from a previous lot detected Protein patched homolog 2 on 10 µg of HeLa cell lysate.

      Immunohistochemistry Analysis: 1;1,000 dilution from a previous lot detected Protein patched homolog 2 in human placenta tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Protein patched homolog 2 at and around the extracellular domain.
      EpitopeExtracellular Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Protein patched homolog 2.
      Species Reactivity
      • Human
      • Mouse
      • Canine
      • Horse
      Species Reactivity NoteReacts with human. Predicted to react with mouse, canine, and equine based on 100% sequence homology. Chicken and cow (92%).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described.
      Gene Symbol
      • PTCH2
      • PTC2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).

      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.

      INVOLVEMENT IN DISEASE: Defects in PTCH2 are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome).

      Defects in PTCH2 are a cause of sporadic basal cell carcinoma (BCC) [MIM:605462].

      SEQUENCE SIMILARITIES: Belongs to the patched family.

      Contains 1 SSD (sterol-sensing) domain.
      Molecular Weight115 kDa was observed and 130 kDa was calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Protein patched homolog 2 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications