05-911 | Anti-RAP1 Antibody, clone 4C8/1

05-911
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-911
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-RAP1 Antibody, clone 4C8/1
      References
      Product Information
      FormatPurified
      Applications
      ApplicationAnti-RAP1 Antibody, clone 4C8/1 is a high quality Mouse Monoclonal Antibody for the detection of RAP1 & has been validated in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHuman Rap1 Clone 4C8/1
      Cloneclone 4C8/1
      HostMouse
      SpecificityRap1
      IsotypeIgG2b
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TERF2IP
      • hRap1
      • DRIP5
      • RAP1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NYB0 # May play a role in telomere length regulation.
      SIZE: 399 amino acids; 44260 Da
      SUBUNIT: Homodimer. Binds to TRF2 (but not TRF1) with its C- terminus.
      SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with telomeric DNA in interphase and metaphase cells.
      TISSUE SPECIFICITY: Ubiquitous. Highly expressed.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q9NYB0 ## Contains 1 BRCT domain. & Contains 1 Myb-like domain.
      MISCELLANEOUS: Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.
      Molecular WeightMr 50kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on HeLa nuclear extracts
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-RAP1, clone 4C8/1 - 30404 30404
      Anti-Rap1, clone 4C8/1 2476730

      References

      Reference overviewPub Med ID
      Telomere stability genes are not mutated in osteosarcoma cell lines.
      Savage, Sharon A, et al.
      Cancer Genet. Cytogenet., 160: 79-81 (2005)  2005

      Show Abstract
      15949576 15949576

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      Catalogue Number Description  
      12-309 HeLa Nuclear Extract Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies