07-1814 | Anti-RCC1 (Trimethyl Ser2) Antibody

07-1814
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1814
      DescriptionAnti-RCC1 (Trimethyl Ser2) Antibody
      Alternate Names
      • regulator of chromosome condensation 1
      • chromosome condensation 1
      • Cell cycle regulatory protein
      • Chromosome condensation protein 1
      • guanine nucleotide-releasing protein
      Background InformationThe Regulator of Chromosome Condensation 1 (RCC1) is a critical cell cycle regulator. This protein is involved in regulating the onset of chromosome condensation during S phase. The RCC1 protein binds to chromatin and interacts with Ran, a nuclear GTP-binding protein. This complex acts as a guanine-nucleotide dissociation stimulator (GDS) by promoting the loss of bound GDP and the uptake of fresh GTP.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HEPG2 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-RCC1 (Trimethyl Ser2) Antibody is a Rabbit Polyclonal Antibody for detection of RCC1 also known as regulator of chromosome condensation 1 & has been validated in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application Notes Immunocytochemistry
      A representitive lot of this antibody was reported to work in Ic. See Chen, T., et al. (2007) Nat Cell Biol, 9(5):596-603.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human RCC1.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes RCC1 methylated at serine 2. Moderate cross reactivity with the unmodified form of the protein has been observed.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RCC1
      • SHEP1
      • CHC1
      • RCC1-I
      • HERC2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.

      SUBUNIT STRUCTURE: Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation.

      SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Becomes dispersed throughout the cytoplasm during mitosis.

      MISCELLANEOUS: Patients with Raynaud disease produce antibodies that bind to RCC1.

      SEQUENCE SIMILARITIES: Contains 7 RCC1 repeats.
      Molecular Weight~ 50 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEPG2 cell lysate.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected RCC1 on 10 µg of HEPG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies