04-413 | Anti-Rap1GAP Antibody, rabbit monoclonal

04-413
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RFC, IF, IP, WB, IH(P)RbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-413
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Rap1GAP Antibody, rabbit monoclonal
      Alternate Names
      • RAP1 GTPase activating protein
      • RAP1GA1
      • rap1GAPII
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
      Applications
      ApplicationAnti-Rap1GAP Antibody, rabbit is an antibody against Rap1GAP for use in FC, IF, IP, WB, IH(P).
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesSuggested Dilutions:
      Immunoblot Analysis: 1:50,000
      Immunoprecipitation: 1:60
      Flow Cytometry: 1:50
      Immunohistochemistry (PE): 1:100 - 1:250
      Immunfluorescence Staining: 1:100 - 1:250
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the region N-terminus of the GoLoco motif of human Rap1GAP.
      HostRabbit
      SpecificityRecognizes the domain N-terminal to the GoLoco motif of Rap1GAP.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RAP1GAP
      • KIAA0474
      • RAP1GA1
      • Rap1GAP
      • rap1GAPII
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P47736 # GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
      SIZE: 663 amino acids; 73391 Da
      SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein.
      TISSUE SPECIFICITY: Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
      SIMILARITY: SwissProt: P47736 ## Contains 1 GoLoco domain. & Contains 1 Rap-GAP domain.
      Molecular Weight85 and 95 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-IL-1 beta - DAM1739191 DAM1739191
      Anti-Rap1GAP (Rabbit monoclonal IgG) - 2118897 2118897
      Anti-Rap1GAP (Rabbit monoclonal IgG) - 2159618 2159618
      Anti-Rap1GAP (Rabbit monoclonal IgG) - 1963065 1963065
      Anti-Rap1GAP (Rabbit monoclonal IgG) - 2095220 2095220
      Anti-Rap1GAP (Rabbit monoclonal IgG) - 2188440 2188440
      Anti-Rap1GAP (Rabbit monoclonal IgG) - 2199565 2199565
      Anti-Rap1GAP (Rabbit monoclonal IgG) - 2204881 2204881
      Anti-Rap1GAP (Rabbit monoclonal IgG) - JBC1371295 JBC1371295
      Anti-Rap1GAP - 1980378 1980378

      References

      Reference overviewPub Med ID
      Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII
      Jordan, J Dedrick, et al
      J Biol Chem, 280:11413-21 (2005)  2005

      15657046 15657046
      Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability
      Tsygankova, Oxana M, et al
      J Biol Chem, 279:5501-7 (2004)  2004

      14660640 14660640