04-959 | Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2

04-959
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBAHmPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-959
      DescriptionAnti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2
      Alternate Names
      • RAR-related orphan receptor C
      • RAR-related orphan receptor gamma
      • retinoic acid-binding receptor gamma
      • nuclear receptor ROR-gamma
      • retinoid-related orphan receptor gamma
      • Nuclear receptor RZR-gamma
      • RZR-GAMMA
      • Nuclear receptor subfamily 1 group F member 3
      • RAR-related orphan receptor C, isoform a
      • Retinoid-related orphan receptor-gamma
      Background InformationRetinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.
      References
      Product Information
      FormatPurified
      Control
      • EL4 cell lysate
      PresentationPurified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect Retinoid-Related Orphan Receptor γ T using this Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2 validated for use in WB, FC & IF.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHistidine-tagged recombinant protein corresponding to mouse Retinoid-Related Orphan Receptor γ T (RORγT).
      EpitopeUnknown
      CloneRORg2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostArmenian Hamster
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RORG
      • RZRG
      • NR1F3
      • RORC
      • TOR
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Orphan nuclear receptor. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.

      SUBCELLULAR LOCATION: Nucleus Probable.

      TISSUE SPECIFICTY: Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes. Neither isoform is expressed in spleen or bone marrow.

      SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.

      Contains 1 nuclear receptor DNA-binding domain.
      Molecular Weight~52 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in EL4 cell lysate.

      Western Blot Analysis: 2 µg/mL of this antibody detected Retinoid-Related Orphan Receptor γ T (RORγT) in 10 µg of EL4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Retinoid-Related Orphan Receptor T, clone RORg2 - 1951088 1951088
      Anti-Retinoid-Related Orphan Receptor T, clone RORg2 - 2224484 2224484
      Anti-Retinoid-Related Orphan Receptor T, clone RORg2 - 2358865 2358865
      Anti-Retinoid-Related Orphan Receptor T, clone RORg2 - NG1898232 NG1898232
      Anti-Retinoid-Related Orphan Receptor T, clone RORg2 - NRG1776165 NRG1776165
      Anti-Retinoid-Related Orphan Receptor #947; T, clone RORg2 - 2039822 2039822
      Anti-Retinoid-Related Orphan Receptor γ T, clone RORg2 - 2461553 2461553
      Anti-Retinoid-Related Orphan Receptor γ T, clone RORg2 -2721659 2721659
      Anti-Retinoid-Related Orphan Receptor γ T, clone RORg2 -2861660 2861660