06-668 | Anti-Rsk1/MAPKAP Kinase 1a Antibody

06-668
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-668
      Replaces04-417
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Rsk1/MAPKAP Kinase 1a Antibody
      References
      Product Information
      FormatAffinity Purified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, 5mg/ml BSA before the addition of glycerol to 30%
      Applications
      ApplicationThis Anti-Rsk1/MAPKAP Kinase 1a Antibody is validated for use in IP, WB for the detection of Rsk1/MAPKAP Kinase 1a.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to residues 695-708 of mouse Rsk1 and 706-719 of human Rsk1 [CNSSKPTPQLKPIES]
      HostRabbit
      SpecificityRsk1
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • RPS6KA1
      • HU-1
      • RSK-1
      • MAPKAPK1A
      • RSK
      • pp90RSK1
      • p90S6K
      • RSK1
      Purification MethodImmunoaffinity Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15418 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
      COFACTOR: Magnesium.
      SIZE: 735 amino acids; 82723 Da
      SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.
      PTM: Autophosphorylated on Ser-380, as part of the activation process.
      SIMILARITY: SwissProt: Q15418 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
      Molecular Weight90kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on Rsk1/MAPKAP-K1a from EGF-stimulated A431 RIPA cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Rsk1/MAPKAP Kinase 1a - 16347 16347
      Anti-Rsk1/MAPKAP Kinase 1a - 21042 21042
      Anti-Rsk1/MAPKAP Kinase 1a - 24840 24840
      Anti-Rsk1/MAPKAP-K1a (rabbit immunoaffinity purified IgG) - DAM1437271 DAM1437271
      Anti-Rsk1/MAPKAP-K1a -2568517 2568517

      References

      Reference overviewApplicationPub Med ID
      Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 Are Involved in the Phosphorylation of STAT3
      Zhang, Y., et al
      J Biol Chem, 278:12650-9 (2003)  2003

      Kinase Assay12562765 12562765
      Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation
      Xing, J., et al
      Mol Cell Biol, 18:1946-55 (1998)  1998

      Kinase Assay9528766 9528766
      Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway.
      Foltz, I N, et al.
      J. Biol. Chem., 272: 3296-301 (1997)  1997

      Show Abstract
      9013568 9013568
      Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.
      Erikson, R L
      J. Biol. Chem., 266: 6007-10 (1991)  1991

      2007561 2007561
      Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction.
      Hwang, P M, et al.
      Proc. Natl. Acad. Sci. U.S.A., 87: 7395-9 (1990)  1990

      Show Abstract
      2217172 2217172
      Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.
      Alcorta, D A, et al.
      Mol. Cell. Biol., 9: 3850-9 (1989)  1989

      2779569 2779569

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      Included Positive Control

      Catalogue Number Description  
      12-302 EGF-Stimulated A431 Cell Lysate Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies